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Mini-Reviews in Organic Chemistry

Author(s): Santosh Raut, Atul Tidke, Bharat Dhotre and Pathan Mohd Arif*

DOI: 10.2174/1570193X16666190430160324

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Different Strategies to the Synthesis of Indazole and its Derivatives: A Review

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Abstract

In this review, works of various researchers working on the synthesis of indazole and their related compound are cited. The review comprises of methodologies for the synthesis of 1H and 2H indazole derivatives, along with some pharmacological activities. In this review, research papers published in various peer-reviewed journals between the year 2000 and year 2017 are enlisted in alphabetical order.

Keywords: 1H and 2H indazole, biological activity, synthetic methods, copper catalyzed reaction, π electron heterocyclic systems, three component regioselective synthesis.

Graphical Abstract

[1]
Miloudi, A.; El Abed, D.; Boyer, G. Phenylation of aminoindazole derivatives. Arab. J. Chem., 2017, 10(8), 1184-1187.
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[2]
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Wang, C.D.; Liu, R.S. Silver-catalyzed [3+2]-cycloaddition of benzynes with diazocarbonyl species via a postulated (1H-indazol-1-yl)silver intermediate. Org. Biomol. Chem., 2012, 10(45), 8948-8952.
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Sun, F.; Feng, X.; Zhao, X.; Huang, Z. Bin; Shi, D.Q. An efficient synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent. Tetrahedron, 2012, 68(20), 3851-3855.
[http://dx.doi.org/10.1016/j.tet.2012.03.043]
[25]
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[http://dx.doi.org/10.1002/jhet.1089]
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Fang, Y.; Wu, C.; Larock, R.C.; Shi, F. Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes. J. Org. Chem., 2011, 76(21), 8840-8851.
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