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Letters in Organic Chemistry

Author(s): Anamika Sharma, Zainab M. Almarhoon, Ayman El-Faham*, Beatriz G. de la Torre* and Fernando Albericio*

DOI: 10.2174/1570178616666190409145118

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Efficient Route for Synthesis of Enamines from 1,3-Alkyl-2-Thioxodihydropyrimidine-4,6(1H,5H)-dione Enols

Page: [538 - 540] Pages: 3

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Abstract

Here we report a greener approach for the synthesis of enamines from enols of 1,3-alkyl-2- thioxodihydropyrimidine-4,6(1H,5H)-dione (thiobarbituric acid) acid using ammonium chloride and ethanol as solvents. This protocol removes the need for catalysts or harsh conditions.

Keywords: Thiobarbituric acid, enols, enamines, greener approach, ammonium chloride, HPLC.