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Current Bioactive Compounds

Author(s): Little Nagyal, Amit Kumar, Rishipal Sharma, Rohit Yadav, Pratibha Chaudhary and Rajeev Singh*

DOI: 10.2174/1573407215666190409105351

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Bioinorganic Chemistry of Platinum(IV) Complexes as Platforms for Anticancer Agents

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Abstract

The current review focuses on the comprehensive studies of platinum-based complexes that are known to exhibit anticancer properties. The research on metal-particle work has helped in treating sicknesses which plays an imperative part in therapeutic bioinorganic science. Understanding the biochemistry of the detoxification mechanism of metals can help in advancing as well as enhancing the anticancer property of metal complexes for several types of a tumour. The classifications of complexes discussed have been done on the basis of Platinum oxidation states and binding sites of the ligands. Further background and current status of Pt(IV) complexes are briefly explained along with a special reference to Structural Activity Relationships and Mode of Action. The coordination chemistry of Pt(IV) has been summarised and Pt(IV) complexes are reviewed on the basis of binding of Pt(IV) with Human Serum Albumin and DNA. Finally, the results were summarized and concluded emphasizing on the most important features.

Keywords: Platinum complexes, anticancer, structural activity relationships, human serum albumin, DNA, chemotherapy.

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