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Drug Delivery Letters

Author(s): Ravindra V. Movliya and Pravinkumar M. Patel*

DOI: 10.2174/2210303109666190319165209

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Role of Dendrimer in Drug Solubilization - A Review

Page: [265 - 276] Pages: 12

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Abstract

Objective: Dendrimers, a new class of synthetic polymers proved themselves very useful tools for biomedical application due to their unique characteristics including water solubility, uniform size and shape, defined molecular weight, multivalency, biological compatibility and internal cavities. The hydrophobicity of a drug molecule creates hurdles in the development of effective dosage form and presents insufficient drug delivery to the target site.

Methods: Solubility enhancement is one of the key properties of a dendrimer. The hydrophobic drug molecules are entrapped in the cavities of a dendrimer by complexation and get solubilized in the aqueous solution.

Conclusion: The present article contains information on dendrimer and its biomedical application such as API solubility. The detailed study presents year wise survey of different research articles, research papers, reviews and patents on dendrimer and its application in drug solubility.

Keywords: Dendrimer, solubility, biomedical, complexation, PAMAM, drug carrier.

Graphical Abstract

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