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Letters in Organic Chemistry

Author(s): Jieyu Zhang, Qiumin Ke, Jiaying Chen, Jian Yu* and Guobing Yan*

DOI: 10.2174/1570178616666190311162001

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Trifluoroacetylation of Anilines with Ethyl Trifluoropyruvate Mediated by Copper(I) Chloride

Page: [860 - 864] Pages: 5

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Abstract

A novel copper(I)-mediated trifluoroacetylation of anilines with ethyl trifluoropyruvate as a trifluoroacetylating reagent has been developed. Although this protocol could provide good yields in most cases, the reaction exhibited the obvious electronic and steric effects of substituents. The trace amount of products was only obtained for the substrates with ortho-substituted or electron-deficient groups.

Keywords: Trifluoroacetylation, anilines, ethyl trifluoropyruvate, copper catalysis, cross-coupling, deficient groups.

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