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Current Medicinal Chemistry

Author(s): Kartikey Singh and Rama Pati Tripathi*

DOI: 10.2174/0929867326666190227232721

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An Overview on Glyco-Macrocycles: Potential New Lead and their Future in Medicinal Chemistry

Page: [3386 - 3410] Pages: 25

  • * (Excluding Mailing and Handling)

Abstract

Macrocycles cover a small segment of molecules with a vast range of biological activity in the chemotherapeutic world. Primarily, the natural sources derived from macrocyclic drug candidates with a wide range of biological activities are known. Further evolutions of the medicinal chemistry towards macrocycle-based chemotherapeutics involve the functionalization of the natural product by hemisynthesis. More recently, macrocycles based on carbohydrates have evolved a considerable interest among the medicinal chemists worldwide. Carbohydrates provide an ideal scaffold to generate chiral macrocycles with well-defined pharmacophores in a decorated fashion to achieve the desired biological activity. We have given an overview on carbohydrate-derived macrocycle involving their synthesis in drug design and discovery and potential role in medicinal chemistry.

Keywords: Glyco-macrocycle, glycohybrids, glycoside, cyclic peptide, glycopeptide, glycomimetics, saponins.

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