Biomedical Nano Tools: A Potential New Paradigm for Immunoassays and Immune Detection

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Abstract

Immunoassays are microwell and solid phase based antigen-antibody (Ag/Ab) interactions majorly dependent on immune complex or lattice formation. Most of these assays are aimed at the detection of very minute amount of antigen or antibody. Such biochemical reactions are bound to identify not only the target biomolecule (immunoassay) but also clinically important pathogens (immune detection) because of their remarkable simplicity, specificity and sensitivity. But the existing technology suffers from certain difficulties like affinity and avidity of antigen and antibody, vigorous washing methods, chances of false positive interactions, appropriate probe selection and dependence on carcinogenic (as substrate) or hazardous radioisotopes. An urgent need is being felt to ensure more specific, powerful and versatile platform for robust detection of immune reactions. In this scenario, application of nanomaterials in immunoassays may pave a new horizon for immune based detection. Optically active nanomaterial dependent detection reduces the chance of false positive results as well as chromogen or radioisotope dependence and time and cost incurred for those. In this perspective, the immense potential of biomedical nanodevices in immunoassays is summarized in this article. Moreover, application of gold nanoparticles in all types of biosensor (electrochemical, optical, surface enhanced Raman scattering based and engineered) is also discussed as a specific tool in nano immunosensors.

Keywords: Nano immunosensors, surface enhanced raman scattering, point of care device, carbon nanomaterials, gold nanoparticle, biomedical nano tools.

Graphical Abstract

[1]
Bhattacharya R, Mukherjee P. Biological properties of “naked” metal nanoparticles. Adv Drug Deliv Rev 2008; 60(11): 1289-306.
[2]
Caseri W. Nanocomposites of polymers and metals or semiconductors: Historical background and optical properties. Macromol Rapid Commun 2000; 21(11): 705-22.
[3]
Erren TC. Prizes to solve problems in and beyond medicine, big and small: It can work. Med Hypotheses 2007; 68(4): 732-4.
[4]
Feynman RP. “There’s plenty of room at the bottom,” in Miniaturization Gilbert HD Ed. New York: Reinhold Publishing 1961; pp. 282-96.
[5]
Taniguchi N. "On the Basic Concept of 'Nano- Technology'," Proc Intl Conf Prod London, Part II, British Society of Precision Engineering 1974.
[6]
Drexler E. Engines of Creation: The Coming Era of Nanotechnology and Nanosystems: Molecular Machinery, Manufacturing, and Computation. New York, Anchor Press. 1986.
[7]
Tan W, Wang K, He X, et al. Bionanotechnology based on silica nanoparticles. Med Res Rev 2004; 24(5): 621-38.
[8]
Hochella MF, Lower SK, Maurice PA, et al. Nanominerals, mineral nanoparticles, and earth systems. Science 2008; 319(5870): 1631-5.
[9]
Charra F, Gota-Goldmann S. Mesoscopic and nanostructured materials, in Springer Handbook of Condensed Matter and Materials Data, Martienssen W, Warlimont H, Ed, Berlin, Springer, pp. 1031-71. 2005.
[10]
Alivisatos AP. Semiconductor clusters, nanocrystals, and quantum dots. Science 1996; 271: 933-7.
[11]
Tervonen T, Linkov I, Figueira JR, Steevens J, Chappell M, Merad M. Risk-based classification system of nanomaterials. J Nanopart Res 2009; 11: 757-66.
[12]
Wu L, Yan F, Ju H. An amperometric immunosensor for separation-free immunoassay of CA125 based on its covalent immobilization coupled with thionine on carbon nanofiber. J Immunol Methods 2007; 322(2007): 12-9.
[13]
Abdorahim M. RabieeSanaz M, Alhosseini N, et al Nanomaterials-based electrochemical immunosensors for cardiac troponin recognition: An illustrated review. Trends Analyt Chem 2016; 82: 337-47.
[14]
Gomes Filho SLR, Dias ACMS, Silva MMS, Silva BVM. Dutra RF. A carbon nanotube-based electrochemical immunosensor for cardiac troponin T. Microchem J 2013; 109: 10-5.
[15]
Omidfar PK, Darzianiazizi M, Ahmadi A, Daneshpour M, Shirazi H. A high sensitive electrochemical nanoimmunosensor based on Fe3O4/TMC/Au nanocomposite and PT-modified electrode for the detection of cancer biomarker epidermal growth factor receptor. Sensors and Actuators B: Chemical 2015; 220, 1 1311-1319.
[16]
Yoon JY. Introduction to Biosensors: From Electric Circuits to Immunosensors Chapter 1 Second edition Springer publisher 2016.
[17]
Ben Haddada M, Hu D, Salmain M, et al. Gold nanoparticle-based localized surface plasmon immunosensor for staphylococcal enterotoxin A (SEA) detection. Anal Bioanal Chem 2017; 409: 6227.
[18]
Liu XH, Wang Y, Chen P, et al. Biofunctionalized gold nanoparticles for colorimetric sensing of Botulinum neurotoxin A light chain. Anal Chem 2014; 86(5): 2345-52.
[19]
Hinterwirth H, Stübiger G, Lindner W, Lämmerhofer M. Gold nanoparticle-conjugated anti-oxidized low-density lipoprotein antibodies for targeted Lipidomics of oxidative stress biomarkers. Anal Chem 2013; 85(17): 8376-84.
[20]
Li Y, Zhang Y, Han J, Chu PK, Feng J, Dong Y. A sensitive non-enzymatic immunosensor composed of silver nanoflowers for squamous cell carcinoma antigen. RSC Advances 2017; 7: 2242-8.
[21]
Wang Y, Zhang Y, Wu D, et al. Ultrasensitive label-free electrochemical immunosensor based on multifunctionalized graphene nanocomposites for the detection of alpha fetoprotein. Scientific Reports 2017; 7: 42361.
[22]
Otis JB, Zong H, Kotylar A, et al. Dendrimer antibody conjugate to target and image HER-2 overexpressing cancer cells. Oncotarget 2016; 7(24): 36002-13.
[23]
Hill E, Shukla R, Park SS, Baker JR. Synthetic PAMAM-RGD conjugates target and bind to odontoblast-like MDPC 23 cells and the predentin in tooth organ cultures. Bioconjug Chem 2007; 18: 1756-62.
[24]
Kahraman M, Mullen ER, Korkmaz A, Wachsmann-Hogiu S. Fundamentals and applications of SERS-based bioanalytical sensing. Nanophotonics 2017; 6(5): 831-52.
[25]
Ni J, Lipert RJ, Dawson GB, Porter MD. Immunoassay readout method using extrinsic Raman labels adsorbed on immune gold colloids. Anal Chem 1999; 71: 4903-8.
[26]
Qian X, Peng XH, Ansari DO, et al. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat Biotechnol 2008; 26: 83-90.
[27]
Liang Y, Gong JL, Huang Y, et al. Biocompatible core-shell nanoparticle-based surface-enhanced Raman scattering probes for detection of DNA related to HIV gene using silica coated magnetic nanoparticles as separation tools. Talanta 2007; 72: 443-9.
[28]
Han XX, Cai LJ, Guo J. Fluorescein isothiocyanate linked immunoabsorbent assay based on surface-enhanced resonance Raman scattering. Anal Chem 2008; 80: 3020-4.
[29]
Wang X, Niessner R, Tang D, Knopp D. Nanoparticle-based immunosensors and immunoassays for aflatoxins. Anal Chim Acta 2016; 912: 10-23.
[30]
Ko J, Lee C, Choo J. Highly sensitive SERS-based immunoassay of aflatoxin B1 using silica-encapsulated hollow gold nanoparticles. J Hazard Mater 2015; 285: 11-7.
[31]
García-Fernández J, Trapiella-Alfonso L, Costa-Fernández JM, Pereiro R, Sanz-Medel A. A Quantum Dot-Based immunoassay for screening of tetracyclines in bovine muscle. J Agric Food Chem 2014; 62(7): 1733-40.
[32]
Savin M, Mihailescu CM, Matei I. A quantum dot-based lateral flow immunoassay for the sensitive detection of human heart fatty acid binding protein (hFABP) in human serum. Talanta 2018; 1(178): 910-5.
[33]
Zhou L, Zhu A, Lou X, et al. Universal quantum dot-based sandwich-like immunoassay strategy for rapid and ultrasensitive detection of small molecules using portable and reusable optofluidic nano-biosensing platform. Anal Chim Acta 2016; 905: 140-8.
[34]
Farimani AB, Heiranian M, Min K, Aluru NR. Antibody subclass detection using graphene nanopores. J Phys Chem Lett 201; 8(7): 670-76.
[35]
Afsahia S, Lerner MB, Goldstein JM. Novel graphene-based biosensor for early detection of Zika virus infection. Biosensors and Bioelectronics 2018; 100: 85-8.
[36]
Huang A, Li W, Shi S, Yao T. Quantitative fluorescence quenching on antibody-conjugated graphene oxide as a platform for protein sensing. Scientific Reports 2017; 7: 40772.
[37]
Finikova O, Galkin A, Rozhkov V, Cordero M, Hägerhäll C, Vinogradov S. Porphyrin and tetrabenzoporphyrin dendrimers: tunable membrane-impermeable fluorescent pH nanosensors. J Am Chem Soc 2003; 125(16): 4882-93.
[38]
Walsh R, Morales JM, Skipwith CG, Ruckh TT, Clark HA. Enzyme-linked DNA dendrimer nanosensors for acetylcholine. Scientific Reports 2015; 5: 14832.
[39]
Shankar D, Unnikrishnan PM, Venkatasubramaniam P. Need to develop inter-cultural standards for quality, safety and efficacy of traditional Indian systems of medicine. Curr Sci 2007; 92: 1499-505.
[40]
Finkelstein AE, Walz DT, Batista V, Mizraji M, Roisman F, Misher A. Auranofin. New oral gold compound for treatment of rheumatoid arthritis. Ann Rheum Dis 1976; 35: 251-7.
[41]
Loo C, Lowery A, Halas N, West J, Drezek R. Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett 2005; 5: 709-11.
[42]
Han G, Ghosh P, Rotello VM. Functionalized gold nanoparticles for drug delivery. Nanomedicine 2007; 2: 113-23.
[43]
Murray WA, Barnes WL. Plasmonic Materials. Adv Mater 2007; 19: 3771-82.
[44]
McMahon SJ, Mendenhall MH, Jain S, Currell F. Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles. Phys Med Biol 2008; 53: 5635-51.
[45]
Das S, Debnath N, Mitra S, Datta A, Goswami A. Comparative analysis of stability and toxicity profile of three differently capped gold nanoparticles for biomedical usage. Biometals 2012; 25: 1009-22.
[46]
Raveendran P, Fu J, Wallen SL. ‘Completely “green” synthesis and stabilization of metal nanoparticles’. J Am Chem Soc 2003; 46: 13940-1.
[47]
Vaseeharan B, Ramasamy P, Chen JC. Antibacterial activity of silver nanoparticles (AgNps) synthesized by tea leaf extracts against pathogenic Vibrio harveyi and its protective efficacy on juvenile Feneropenaeus indicus. Lett Appl Microbiol 2010; 50: 352-6.
[48]
Begum NA, Mondal S, Basu S, Laskar RA, Mandal D. Biogenic synthesis of Au and Ag nanoparticles using aqueous solutions of Black Tea leaf extracts. Colloids Surf B Biointerfaces 2009; 71: 113-8.
[49]
Nune SK, Chanda N, Shukla R, et al. Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles. J Mater Chem 2009; 19: 2912-20.
[50]
Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M. Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog 2006; 22: 577-83.
[51]
Shankar SS, Rai A, Ankamwar B, Singh A, Ahmad A, Sastry M. Biological synthesis of triangular gold nanoprisms. Nat Mater 2004; 3: 482-8.
[52]
Mukherjee P, Ahmad A, Mandal D. Bioreduction of AuCl−4 ions by the fungus, verticillium sp.and surface trapping of the gold nanoparticles formed. Angew Chem 2001; 40: 3585-8.
[53]
Mukherjee P, Senapati S, Mandal D, et al. Extracellular synthesis of gold nanoparticles by the fungus Fusarium oxysporum. ChemBioChem 2002; 3: 461-3.
[54]
Sainsbury T, Ikuno T, Okawa D, Pacile´ D, Fre’chet JMJ, Zettl A. Self-assembly of gold nanoparticles at the surface of amine- and thiol-functionalized boron nitride nanotubes. J Phys Chem C 2007; 111: 12992-9.
[55]
Mukherjee P, Bhattacharya R, Patra CR, Mukhopadhyay D. Nanogold in Cancer Therapy and Diagnosis, in Nanomaterials for Cancer Diagnosis, of Series -Nanotechnologies for the Life Sciences. Challa Kumar Eds., Wiley-VCH, Weinheim 2007; 7: 86-120.
[56]
Hainfiels J. Slatkin D Media and Methods for Enhanced Medical Imaging. U.S. Patent 2004; 6(818): 199.
[57]
Li Y, Schluesenerb HJ, Xu S. Gold nanoparticle-based biosensors. Gold Bull 2010; 43: 29-41.
[58]
Xianyu Y, Wang Z, Jiang X. A plasmonic nanosensor for immunoassay via enzyme-triggered click chemistry. ACS Nano 2014; 12: 12741-7.
[59]
Nagatani N, Tanaka R, Yuhi T, et al. Gold nanoparticle-based novel enhancement method for the development of highly sensitive immunochromatographic test strips. Sci Technol Adv Mater 2006; 7: 270.
[60]
Yoon KJ, Seo HK, Hwang H, et al. Bioanalytical application of sers immunoassay for detection of prostate-specific antigen. Bull Korean Chem Soc 2010; 31: 1215-8.
[61]
Shin MH, Hong W, Sa Y, et al. Multiple detection of proteins by sers-based immunoassay with core shell magnetic gold nanoparticles. Vib Spectrosc 2014; 72: 44-9.
[62]
Smolsky J, Kaur S, Hayashi C, Batra SK, Krasnoslobodtsev AV. Surface-Enhanced raman scattering-based immunoassay technologies for detection of disease biomarkers. Biosensors 2017; 7(1): 7.
[63]
Lipka J, Semmler-Behnke M, Sperling RA, et al. Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection. Biomaterials 2010; 31: 6574-81.
[64]
Lee SH, Bae KH, Kim SH, Lee KR, Park TG. Amine functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers. Int J Pharm 2008; 364: 94-101.
[65]
Sun L, Liu D, Wang Z. Funtional gold nanoparticle-peptide complexes as cell targeting agents. Langmuir 2008; 24: 10293-7.
[66]
Bastis NG, Sanchez-Tillo E, Pujals S, et al. Peptides conjugated to gold nanoparticles induce macrophage activation. Mol Immunol 2009; 46: 743-8.
[67]
Liu Y, Liu Y, Mernaugh RL, Zeng X. Single chain fragment variable recombinant antibodyfunctionalized gold nanoparticles for a highly sensitive colorimetric immunoassay. Biosens Bioelectron 2009; 24: 2853-7.
[68]
Nam JM, Thaxton CS, Mirkin CA. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 2003; 301(5641): 1884-6.
[69]
Han MS, Lytton-Jean AKR, Mirkin CA. A gold nanoparticle based approach for screening triplex DNA binders. J Am Chem Soc 2006; 128(15): 4954-5.
[70]
Sperling RA, Gil PR, Zhang F, Zanella M, Parak WJ. Biological applications of gold nanoparticles. Chem Soc Rev 2008; 37(9): 896-908.
[71]
Everts M. Thermal scalpel to target cancer. Expert Rev Med Devices 2007; 4(2): 131-6.
[72]
Qin Z, Warren C, Chan W, et al. Significantly improved analytical sensitivity of lateral flow immunoassays by thermal contrast. Angew Chem Int Ed Engl 2012; 51(18): 4358-61.
[73]
Chen J, Wakefield LM, Goldstein DJ. Capillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnostics. J Transl Med 2015; 13: 182.