Generic placeholder image

Current Drug Discovery Technologies

Author(s): Marjan Mahjour* and Arash Khoushabi

DOI: 10.2174/1570163816666190121145653

DownloadDownload PDF Flyer Cite As
An Herbal H2 Blocker in Melasma Treatment

Page: [272 - 277] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

Background: Melasma is a skin pigmentation disorder that remains resistant to available therapies. The exact cause of melasma is unknown. Histamine is an inflammatory factor. Its involvement in pigmentation is obscure. The aim of this study is to introduce an herbal antihistamine H2 receptor which is effective in these disorders.

Methods: This is a review study by searching the electronic databases and also Persian Medicine books, from 2000 to 2018 by the keywords such as H2 antagonist, H2 blocker and melasma.

Results: According to the researched studies, histamine can induce melanogenesis and melasma after a series of stages in the body. Also, Histamine, through receptors 2, triggers melasma. Therefore, it can be said that antihistamine H2 receptor can be effective in melasma. Considering chemical antihistamine, H2 receptors have side effects, such as digestive problems, H2 antagonists can be used in the treatment of diseases such as dyspepsia but they have multiple complications. On the other hand, there is an herbal H2 antagonist that can be useful for melasma due to having some special properties.

Conclusion: Herbal H2 blockers should be noted in melasma treatment along with the topical drugs.

Keywords: Melasma, Herbal drugs, H2 antagonist, H2 blocker, histamine, phytomedicine.

Graphical Abstract

[1]
Mahjour M, Khoushabi A, Noras MR, Salari R. The Relationship Between Herbal Anticoagulants and Melasma. Journal of Skin and Stem Cell 2016; 3(2) e65578
[http://dx.doi.org/10.5812/jssc.65578]
[2]
Mahjour M, Noras MR, Khoushabi A, Salari R. The Role of Digestive Disorders in Melasma. Traditional and Integrative Medicine 2018; 3(1): 18-22.
[3]
Katsambas A, Soura E. Quality of Life in Melasma Melasma and Vitiligo in Brown Skin. Springer 2017; pp. 169-75.
[http://dx.doi.org/10.1007/978-81-322-3664-1_18]
[4]
Dairina Y. Hubungan kadar glutation peroksidase plasma dengan melasma. Universitas Gadjah Mada 2016.
[5]
Passeron T. Melasma pathogenesis and influencing factors - an overview of the latest research. J Eur Acad Dermatol Venereol 2013; 27(s1)(Suppl. 1): 5-6.
[http://dx.doi.org/10.1111/jdv.12049] [PMID: 23205539]
[6]
Yoshida Y, Hachiya A, Sriwiriyanont P, et al. Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types. FASEB J 2007; 21(11): 2829-39.
[http://dx.doi.org/10.1096/fj.06-6845com] [PMID: 17475923]
[7]
Bandyopadhyay D. Topical treatment of melasma. Indian J Dermatol 2009; 54(4): 303-9.
[http://dx.doi.org/10.4103/0019-5154.57602] [PMID: 20101327]
[8]
Yoshida M, Takahashi Y, Inoue S. Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes. J Invest Dermatol 2000; 114(2): 334-42.
[http://dx.doi.org/10.1046/j.1523-1747.2000.00874.x] [PMID: 10651995]
[9]
Boparai MK, Korc-Grodzicki B. Prescribing for older adults. Mt Sinai J Med 2011; 78(4): 613-26.
[http://dx.doi.org/10.1002/msj.20278] [PMID: 21748749]
[10]
McNicholl IR. Drug interactions among the antiretrovirals. Curr Infect Dis Rep 2004; 6(2): 159-62.
[http://dx.doi.org/10.1007/s11908-996-0013-9] [PMID: 15023279]
[11]
Dublin S, Walker RL, Jackson ML, Nelson JC, Weiss NS, Jackson LA. Use of proton pump inhibitors and H2 blockers and risk of pneumonia in older adults: a population-based case-control study. Pharmacoepidemiol Drug Saf 2010; 19(8): 792-802.
[http://dx.doi.org/10.1002/pds.1978] [PMID: 20623507]
[12]
Oster G, Huse DM, Delea TE, Colditz GA, Richter JM. The risks and benefits of an Rx-to-OTC switch. The case of over-the-counter H2-blockers. Med Care 1990; 28(9): 834-52.
[http://dx.doi.org/10.1097/00005650-199009000-00012] [PMID: 1976142]
[13]
Liang XJ, Wu BL. Botanical composition and methods of manufacture and use Google Patents 2016.
[14]
Rakesh P, Shilpa S, Vipin K, Kanchan K. Ranitidine hydrochloride: An update on analytical, clinical and pharmacological aspects. J Chem Pharm Res 2016; 8(7): 70-8.
[15]
Yoshida CM, Hubbard JR. Gastroenterology and hepatology Primary Care Medicine for Psychiatrists. Springer 1997; pp. 79-112.
[http://dx.doi.org/10.1007/978-1-4615-5857-6_5]
[16]
Fujii S, Tanimukai H, Kashiwagi Y. Comparison and analysis of delirium induced by histamine h(2) receptor antagonists and proton pump inhibitors in cancer patients. Case Rep Oncol 2012; 5(2): 409-12.
[http://dx.doi.org/10.1159/000341873] [PMID: 22949902]
[17]
Booker A, Johnston D, Heinrich M. The welfare effects of trade in phytomedicines: A multi-disciplinary analysis of turmeric production. World Dev 2016; 77: 221-30.
[http://dx.doi.org/10.1016/j.worlddev.2015.08.024]
[18]
Khodaie L, Sadeghpoor O. Ginger from ancient times to the new outlook. Jundishapur J Nat Pharm Prod 2015; 10(1) e18402
[http://dx.doi.org/10.17795/jjnpp-18402] [PMID: 25866718]
[19]
Sharma K, Joshi N, Goyal C. Critical review of Ayurvedic Varṇya herbs and their tyrosinase inhibition effect. Anc Sci Life 2015; 35(1): 18-25.
[http://dx.doi.org/10.4103/0257-7941.165627] [PMID: 26600663]
[20]
Mahjour M, Khoushabi A, Feyzabadi Z. The role of oligomenorrhea in melasma. Med Hypotheses 2017; 104: 1-3.
[http://dx.doi.org/10.1016/j.mehy.2017.05.006] [PMID: 28673563]
[21]
Akdis CA, Simons FER. Histamine receptors are hot in immunopharmacology. Eur J Pharmacol 2006; 533(1-3): 69-76.
[http://dx.doi.org/10.1016/j.ejphar.2005.12.044] [PMID: 16448645]
[22]
Trevor AJ, Katzung BG, Masters SB. Basic & clinical pharmacology. McGraw-Hill Medical 2009.
[23]
Barbier AJ, Berridge C, Dugovic C, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol 2004; 143(5): 649-61.
[http://dx.doi.org/10.1038/sj.bjp.0705964] [PMID: 15466448]
[24]
Zhang J-M, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin 2007; 45(2): 27-37.
[http://dx.doi.org/10.1097/AIA.0b013e318034194e] [PMID: 17426506]
[25]
Westly E. Nothing to sneeze at. Nature Publishing Group 2010.
[http://dx.doi.org/10.1038/nm1010-1063]
[26]
Nelson DL, Lehninger AL, Cox MM. Lehninger principles of biochemistry. Macmillan 2008.
[27]
Kamohara S, Noparatanawong S. A Coleus forskohlii extract improves body composition in healthy volunteers: An open-label trial. Personalized Medicine Universe 2013; 2: 25-7.
[http://dx.doi.org/10.1016/j.pmu.2013.04.003]
[28]
Erental A, Dickman M, Yarden O. Sclerotial development in Sclerotinia sclerotiorum: awakening molecular analysis of a “Dormant” structure. Fungal Biol Rev 2008; 22(1): 6-16.
[http://dx.doi.org/10.1016/j.fbr.2007.10.001]
[29]
Bopp T, Becker C, Klein M, et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med 2007; 204(6): 1303-10.
[http://dx.doi.org/10.1084/jem.20062129] [PMID: 17502663]
[30]
Mandadi S, Sokabe T, Shibasaki K, et al. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch 2009; 458(6): 1093-102.
[http://dx.doi.org/10.1007/s00424-009-0703-x] [PMID: 19669158]
[31]
Katz O, Waitumbi JN, Zer R, Warburg A. Adenosine, AMP, and protein phosphatase activity in sandfly saliva. Am J Trop Med Hyg 2000; 62(1): 145-50.
[http://dx.doi.org/10.4269/ajtmh.2000.62.145] [PMID: 10761741]
[32]
Inbe H, Watanabe S, Miyawaki M, Tanabe E, Encinas JA. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. J Biol Chem 2004; 279(19): 19790-9.
[http://dx.doi.org/10.1074/jbc.M400360200] [PMID: 15001573]
[33]
Mishra RK, Kumar A, Kumar A. Pharmacological activity of Zingiber officinale. Int J Pharmaceut Chem Sci 2012; 1(3): 1073-8.
[34]
Duke JA. CRC handbook of medicinal spices. CRC press 2002.
[http://dx.doi.org/10.1201/9781420040487]
[35]
Wilson R, Haniadka R, Sandhya P, Palatty PL, Baliga MS. Ginger (Zingiber officinale Roscoe) the Dietary Agent in Skin Care: A Review Bioactive Dietary Factors and Plant Extracts in Dermatology. Springer 2013; pp. 103-11.
[http://dx.doi.org/10.1007/978-1-62703-167-7_11]
[36]
Asif M. Protective role of biological potential curcumin in epileptic seizures and memory impairment Research Journal of Phytomedicine 2015; 1: 01
[37]
Saleem TM, Chetty CM, Ramkanth S, et al. Solanum nigrum Linn.-A review. Pharmacogn Rev 2009; 3(6): 342.
[38]
Drea EJ. Transition of products from prescription to over the counter: The H2 antagonists. J Pharm Pract 1992; 5(1): 22-30.
[http://dx.doi.org/10.1177/089719009200500106]
[39]
Lin H-M, Tseng H-C, Wang C-J, Lin JJ, Lo CW, Chou FP. Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats. Chem Biol Interact 2008; 171(3): 283-93.
[http://dx.doi.org/10.1016/j.cbi.2007.08.008] [PMID: 18045581]
[40]
Lomash V, Parihar S, Jain N, Katiyar A. Effect of Solanum nigrum and Ricinus communis extracts on histamine and carrageenan-induced inflammation in the chicken skin Cellular and molecular biology (Noisy-le-Grand, France) 2010; 56: OL1239-51
[41]
Hameed A, Akhtar N. Comparative chemical investigation and evaluation of antioxidant and tyrosinase inhibitory effects of Withania somnifera (L.) Dunal and Solanum nigrum (L.) berries. Acta Pharm 2018; 68(1): 47-60.
[http://dx.doi.org/10.2478/acph-2018-0007] [PMID: 29453917]
[42]
Perez RM, Perez JA, Garcia LM, Sossa H. Neuropharmacological activity of Solanum nigrum fruit. J Ethnopharmacol 1998; 62(1): 43-8.
[http://dx.doi.org/10.1016/S0378-8741(98)00059-2] [PMID: 9720610]
[43]
Jimoh FO, Adedapo AA, Afolayan AJ. Comparison of the nutritional value and biological activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus. Food Chem Toxicol 2010; 48(3): 964-71.
[http://dx.doi.org/10.1016/j.fct.2010.01.007] [PMID: 20079394]
[44]
Eltayeb EA, Al-Ansari AS, Roddick JG. Changes in the steroidal alkaloid solasodine during development of Solanum nigrum and Solanum incanum. Phytochemistry 1997; 46(3): 489-94.
[http://dx.doi.org/10.1016/S0031-9422(97)00323-3]
[45]
Son Y-O, Kim J, Lim J-C, Chung Y, Chung GH, Lee JC. Ripe fruit of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells. Food Chem Toxicol 2003; 41(10): 1421-8.
[http://dx.doi.org/10.1016/S0278-6915(03)00161-3] [PMID: 12909277]
[46]
Lee SJ, Lim KT. Antioxidative Effects of Glycoprotein Isolated from Solanum nigrum Linne on Oxygen Radicals and its Cytotoxic Effects on the MCF‐7 Cell. J Food Sci 2003; 68(2): 466-70.
[http://dx.doi.org/10.1111/j.1365-2621.2003.tb05695.x]
[47]
Reddy K, Kulkarni K. A clinical trial of Herbolax in constipation during post-operative period. Antiseptic 2001; 7(252)e3
[48]
Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv 2014; 32(6): 1053-64.
[http://dx.doi.org/10.1016/j.biotechadv.2014.04.004] [PMID: 24793420]
[49]
Tu CX, Lin M, Lu SS, Qi XY, Zhang RX, Zhang YY. Curcumin inhibits melanogenesis in human melanocytes. Phytother Res 2012; 26(2): 174-9.
[http://dx.doi.org/10.1002/ptr.3517] [PMID: 21584871]
[50]
Google Patents. 1999.https://books.google.com/advanced_patent_search
[51]
Firyal M, Enas M, Falah H, Muammer T, Zainab K. Synthesis-and characterization of Curcumin Derivative and Its Substitution on Polymer Chain. J Tec Sci 2013.
[52]
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm 2007; 4(6): 807-18.
[http://dx.doi.org/10.1021/mp700113r] [PMID: 17999464]
[53]
Zhongfa L, Chiu M, Wang J, et al. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol 2012; 69(3): 679-89.
[http://dx.doi.org/10.1007/s00280-011-1749-y] [PMID: 21968952]
[54]
Kaiser P, Youssouf MS, Tasduq SA, et al. Anti-allergic effects of herbal product from Allium cepa (bulb). J Med Food 2009; 12(2): 374-82.
[http://dx.doi.org/10.1089/jmf.2007.0642] [PMID: 19459740]
[55]
SÖFW-Journal. 2011; 137(3)availablehttps://www.sofw.com/en/sofw-journal
[56]
Fiocco D, Fiorentino D, Frabboni L, et al. Lavender and peppermint essential oils as effective mushroom tyrosinase inhibitors: a basic study. Flavour Fragrance J 2011; 26(6): 441-6.
[http://dx.doi.org/10.1002/ffj.2072]
[57]
Mizuno S, Kato K, Ono Y, et al. Oral peppermint oil is a useful antispasmodic for double-contrast barium meal examination. J Gastroenterol Hepatol 2006; 21(8): 1297-301.
[http://dx.doi.org/10.1111/j.1440-1746.2006.04131.x] [PMID: 16872313]
[58]
Nath SS, Pandey C, Roy D. A near fatal case of high dose peppermint oil ingestion- Lessons learnt. Indian J Anaesth 2012; 56(6): 582-4.
[http://dx.doi.org/10.4103/0019-5049.104585] [PMID: 23325948]
[59]
Nair B. Final report on the safety assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water. Int J Toxicol 2001; 20(Suppl. 3): 61-73.
[http://dx.doi.org/10.1080/10915810152902592] [PMID: 11766133]
[60]
Inoue T, Sugimoto Y, Masuda H, Kamei C. Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L. Biol Pharm Bull 2002; 25(2): 256-9.
[http://dx.doi.org/10.1248/bpb.25.256] [PMID: 11853178]