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Mini-Reviews in Organic Chemistry

Author(s): Ligia S. da Silveira Pinto, Thatyana R. Alves Vasconcelos and Marcus V.N. de Souza*

DOI: 10.2174/1570193X16666181228101137

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Eco-Friendly Methodologies for the Synthesis of Quinoline Nucleus

Page: [602 - 608] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

The quinoline nucleus is a very important class of heterocyclic aromatic compounds present in several drugs on the market, with synthetic methodologies being necessary to prepare its nucleus and derivatives. Considering that fact, the aim of this review is to describe the development of eco-friendly methodologies for the synthesis of quinoline nucleus and its derivatives in the last five years. Thus, throughout the text are presented varios reagents and catalysts used in the synthesis of quinoline nucleus, the reaction conditions, the advantages of the described methodologies, along with the reaction scheme and some reaction mechanisms.

Keywords: Drugs, green chemistry, quinoline nucleus, antituberculosis drugs, heterocyclic aromatic compounds, Friedländer synthesis.

Graphical Abstract

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