Abstract

This review collects for the first time enantioselective domino reactions promoted by chiral green copper catalysts, covering the literature since the beginning of 2006. It is divided into two parts dealing successively with asymmetric two-component domino reactions and three-component processes. The first part is dedicated to twocomponent asymmetric domino reactions, including Michael-initiated processes, domino reactions based on cyclizations, domino reactions initiated by aldol-type condensations and Friedel–Crafts-initiated domino processes. The second part collects asymmetric threecomponent processes, such as Michael-initiated domino reactions, domino reactions between alkynes, aldehydes and amines, domino reactions based on 1,3-dipolar cycloadditions among the other three-component reactions.

Keywords: Enantioselective domino reactions, copper catalysis, metal catalysis, green chemistry, asymmetric catalysis, chirality.

Graphical Abstract