Abstract

Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed.

Keywords: Kallikrein-Kinin System (KKS), Bradykinin (BK), B1 Receptor (B1R), B2 Receptor (B2R), myocardial ischemia, ischemia/reperfusion, hypoxia/reperfusion, angiogenesis, apoptosis.