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Current Organic Synthesis

Author(s): Mohammed S.T. Makki, Reda M. Abdel-Rahman and Abdulrahman Salim Alharbi*

DOI: 10.2174/1570179415666181105142247

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Synthesis and Anti-Inflammatory Effect of Some More New Fluorinated 3-Substituted Amino/ 3,5-Diamino-1,2,4-Triazine Derivatives as Lamotrigine Analogs

Page: [165 - 172] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Aim and Objective: It is known that the Lamotrigine drug has anti-inflammatory activity. So it was the goal to prepare similar compounds containing fluorine atoms (fluorine-substituted 3,5-diamino-6-aryl- 1,2,4-triazines) as Lamotrigine drug analogs to evaluate them as an anti-inflammatory.

Materials and Methods: The novel fluorine substituted 3,5-diamino-6-aryl-1,2,4-triazines as new Lamotrigine analogs were prepared via aminolysis and/ or ammonolysis of the corresponding 3-thioxo-6-aryl-1,2,4-triazin- 5-ones in ethanolic media.

Results: All the new targets were deduced upon their elemental analysis and spectral data as well as screened as anti-inflammatory agents, where we found that the fluorinated systems 15 and 9-11 exhibited high and more activity.

Conclusion: Simple routes to synthesize some more novel fluorinated Lamotrigine analogs have been reported. The new targets exhibited high and moderate anti-inflammatory probes. Presence of both amino and CF3 groups caused high biological activities of these compounds were studied.

Keywords: Synthesis, fluorinated diamino-1, 2, 4-triazine, lamotrigine, anti-inflammatory, indomethacin drug, lamotrigine analogs.

Graphical Abstract

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