Abstract

1,3-Dicarbonyls are widely used in organic reactions. They are able to perform as precursors of pyrimidinones, pyrroles, quinolones, isoquinolines, triazoles and furans et al. Their great success is rooted in the fact that most 1,3-dicarbonyls are commercial (or easy to prepare), stable and versatile. This review will focus mainly on three kinds of reactivity patterns, broadly known as radical, nucleophilic and electrophilic, and will not consider the asymmetric synthesis. Reactions of 1,3-dicarbonyls with carbocations, aldehydes, ketones, imines, alkenes, arynes, halogen reagents, thiol reagents, amines, azides, phenols, isocyanides and organometallic reagents will be discussed briefly. The collection of references for the present review was from January 1, 2007, and till June 26, 2018. We hope the decennary advances will help our future research in this area.

Keywords: 1, 3-Dicarbonyls, radical, nucleophile, electrophile, mechanism, decade.

Graphical Abstract