[1]
ACC/AHA Guidelines for percutaneous coronary intervention. J. Am. Coll. Cardiol., 2001, 37, 2239i-2249i.
[2]
Quinn, M.J.; Fitzgerald, D.J. Ticlopidine and clopidogrel. Circulation, 1999, 100, 1667-1672.
[3]
Girja, D.; Singh, B.D.; Komal, S. Thienopyridines: Platelets ADP receptor antagonist. J. Drug Deliv. Ther., 2011, 1, 8-16.
[4]
Dominick, J.A.; Ortiz, A.F.; Bernardo, E.; Alfonso, F.; Macaya, C.; Bass, T.; Costa, M.A. Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives. J. Am. Coll. Cardiol., 2007, 49, 1505-1516.
[5]
Wallentin, L. P2Y12 inhibitors: Differences in properties and mechanisms of action and potential consequences for clinical use. Eur. Heart J., 2009, 30, 1964-1977.
[6]
Campbell, K.L.; Cohn, J.R.; Savage, M.P. Clopidogrel hypersensitivity: Clinical challenges and options for management. Expert Rev. Clin. Pharmacol., 2010, 3, 553-561.
[7]
Dobesh, P.P.; Oestreich, J.H. Ticagrelor: Pharmacokinetics, pharmaco-dynamics, clinical efficacy, and safety. Pharmacotherapy, 2014, 34, 1077-1090.
[8]
Calogiuri, G.F.; Alsowaidi, S.; Nettis, E.; Cortellini, G.; Macchia, L.; Vacca, A.; Kounis, N.G. A joint allergist/cardiologist classification for thienopyridines hypersensitivity reactions based on their symptomatic patterns and its impact on the management strategies. Int. J. Cardiol., 2016, 222, 509-514.
[9]
Campbell, K.L.; Cohn, J.R.; Fischman, D.L.; Walinski, P.; Mallya, R.; Jaffrani, W.; Savage, M.P. Management of clopidogrel hypersensitivity without drug interruption. Am. J. Cardiol., 2011, 107, 812-816.
[10]
Simpson, D.G.; Hubaytar, R.T. Hypersensitivity to drugs in the treatment of tuberculosis. Rapid desensitization using cortisone acetate. Am. Rev. Respir. Dis., 1962, 86, 738-739.
[11]
Cheema, A.; Mohammad, A.; Hong, T.; Jakubovic, H.R.; Parmar, G.S.; Sharieff, W.; Garvey, M.B.; Kutryk, M.J.; Fam, N.P.; Graham, J.J.; Chisholm, R.J. Characterization of clopidogrel hypersensitivity reactions and managment with oral steroid without clopidogrel disconntinuatiion. J. Am. Coll. Cardiol., 2011, 58, 1445-1454.
[12]
Dakik, H.A. Successful treatment of clopidogrel hypersensitivity with a seven-days taper of oral corticosteroid. Ann. Pharmacother., 2015, 49, 1077-1078.
[13]
Yang, D.C.; Feldman, D.N.; Kim, L.K.; Minutello, R.M.; Bergman, G.; Wong, S.C.; Swaminathan, R.V. A strategy of ‘treating through’ a prasugrel-induced rash. Int. J. Cardiol., 2013, 168, 4381-4382.
[14]
Cernadas, J.R.; Brockow, K.; Romano, A.; Aberer, W.; Torres, M.J.; Bircher, A.; Campi, P.; Sanz, M.L.; Castells, M.; Demoly, P.; Pichler, W.J. General considerations on rapid desensitization for drug hypersensitivity - A consensus statement. Allergy, 2010, 65, 1357-1366.
[15]
Scherer, K.; Brockow, K.; Aberer, W.; Gooi, J.H.; Demoly, P.; Romano, A.; Schnyder, B.; Whitaker, P.; Cernadas, J.S.; Bircher, A.J. Desensitization in delayed drug hypersensitivity reactions -- an EAACI position paper of the Drug Allergy Interest Group. Allergy, 2013, 68, 844-852.
[16]
Vigo, P.G.; MacDowell, A.L.; Wedner, H.J. Successful desensitization with clopidogrel after a positive skin test. Ann. Allergy Asthma Immunol., 2005, 94, 132.
[17]
Camara, M.G.; Almeda, F.Q. Clopidogrel (Plavix) desensitization: A case series. Catheter. Cardiovasc. Interv., 2005, 65, 525-527.
[18]
Lee-Wong, M.; Gadhvi, D.; Resnick, D. Clopidogrel desensitization. Ann. Allergy Asthma Immunol., 2006, 96, 756-757.
[19]
Oppedijk, B.; Odekerken, D.A. van der, Wildt. J.J.; Melissant, C.F. Rapid oral desensitisation procedure in clopidogrel hypersensitivity. Neth. Heart J., 2008, 16, 21-23.
[20]
Kammer, R.T. Successful clopidogrel desensitization after drug eluting stent implantation. J. Invasive Cardiol., 2009, 21, 134-135.
[21]
Chin, N.; Rangamuwa, K.; Mariasooai, R.; Carnes, J.; Thien, F. Oral antiplatelet agents hypersensitivity and cross reactivity managed by successful desensitization. Asia Pac. Allergy, 2015, 5, 51-54.
[22]
Owen, P.; Garner, J.; Hergott, L. Page RL 2nd. Clopidogrel desensitization: Case report and review of published protocols. Pharmacotherapy, 2008, 28, 259-270.
[23]
Sanchez-Lopez, J.; Munoz-Cano, R.; Batra, J.; Valero, A.; Picado, C. Desensitization to clopidogrel: A growing need. Allergy, 2010, 65, 279-280.
[24]
Walker, N.E.; Fasano, M.B.; Howitz, P.A. Desensitization for the management of clopidogrel hypersensitivity: Initial clinical experience. J. Invasive Cardiol., 2006, 18, 341-344.
[25]
von. Tiehl K.F.; Price, M.J.; Valencia, R.; Ludington, K.J. Teirstein, P.S.; Simon, R.A. Clopidogrel desensitization after drug-eluting stent placement. J. Am. Coll. Cardiol., 2007, 50, 2039-2043.
[26]
Doshi, R.; Enoh, A.; Antonopoulos, P.; Sattar, P. A novel, accelerated method of desensitization in a patient with a documented hypersensitivity reaction to clopidogrel. J. Cardiol. Cases, 2010, 1, e158-e160.
[27]
Fajt, M.; Petrov, A. Clopidogrel hypersensitivity. A novel multi-day outpatient oral desensitization regimen. Ann. Pharmacother., 2010, 44, 11-18.
[29]
Barreira, P.; Cadinha, S.; Malheiro, D.; Moreira, J.P. Desensitization to clopidogrel: A tailor made protocol. Eur. Ann. Allergy Clin. Immunol., 2014, 46, 53-55.
[30]
Calogiuri, G.; Nettis, E.; Di Leo, E.; Foti, C.; Ferrannini, A.; Butani, L. Allopurinol hypersensitivity reactions: Desensitization strategies and new therapeutic alternative molecules. Inflamm. Allergy Drug Targets, 2013, 12, 19-28.
[31]
Fernando, S.L.; Assaa, D.N.A. Rapid and sequential desensitization to both aspirin and clopidogrel. Intern. Med. J., 2010, 40, 596-599.
[32]
Mutnick, J.L. Desensitization to prasugrel: Cardiology’s increased need for allergy consultation. Ann. Allergy Asthma Immunol., 2012, 108, 124-125.
[33]
Cegec, I.I.; Francetic, V.; Erdeljic Turk, K.; Makar Ausperger, M.; Aumiler Radacic, I.; Kraljickovic, I.; Cacic, I.; Likic, R. Pharmacoeconomic analysis comparing clopidogrel desensitization protocol versus ticagrelor for antithrombotic treatment in coronary artery disease patients with clopidogrel hypersensitivity after PCI. Clin. Ther., 2015, 37(Suppl.), e77.
[34]
Lokhandwala, J.; Best, P.; Butterfield, J.; Skelding, K.; Scott, T.; Blankenship, J.; Buckley, J.; Berger, P. Frequency of allergic or hematologic adverse reactions among patients with allergic or hematologic adverse reactions to clopidogrel. Circ. Cardiovasc. Interv., 2009, 2, 348-351.
[35]
Morrow, D.A.; Wiviott, S.D.; White, H.D.; Nicolau, J.C.; Bramucci, E.; Murphy, S.A.; Bonaca, M.P.; Ruff, C.T.; Scirica, B.M.; McCabe, C.H.; Antman, E.M.; Braunwald, E. Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38: An application of the classification system from the universal definition of myocardial infarction. Circulation, 2009, 119, 2758-2764.
[36]
Siu, H.; Kaliyadan, A.; Fischman, D.L.; Nardone, E.; Poll, D.; Savage, M.P. Use of prasugrel in the setting of clopidogrel hypersensitivity. Case report and systematic review of the literature. Platelets, 2016, 27, 824-827.
[37]
Kim, S.H.; Park, S.D.; Baek, Y.S.; Lee, S.Y.; Shin, S.H.; Woo, S.I.; Kim, D.H.; Kwan, J. Prasugrel-induced hypersensitivity skin reaction. Korean Circ. J., 2014, 44, 355-357.
[38]
Deshmukh, A.J.; Pant, S.; Cook, J.; Sachdeva, R.; Rutlen, D.; Uretsky, B.F. Prasugrel-induced rash. Ann. Pharmacother., 2012, 46, 1123-1125.
[39]
Patel, T.N.; Kreindel, M.; Lincoff, A.M. Use of ticlopidine and cilostazol after intracoronary drug-eluting stent placement in a patient with previous clopidogrel-induced thrombotic thrombocytopenic purpura: A case report. J. Invasive Cardiol., 2006, 18, e211-e213.
[40]
Khangura, S.; Gordon, W.L. Prasugrel as an alternative for clopidogrel-associated neutropenia. Can. J. Cardiol., 2011, 27(869), e9-e11.
[41]
Trivier, J.M.; Caron, J.; Mathieu, M.; Cambier, N.; Rose, C. Fatal aplastic anemia associated with clopidogrel. Lancet, 2001, 357, 446.
[42]
Gutiérrez-Fernández, D.; Fuentes-Vallejo, M.S.; Rueda-Ygueravides, M.D.; Foncubierta-Fernández, A.; León-Jiménez, A. Immediate hypersensitivity and delayed hypersensitivity to clopidogrel. Allergol. Immunopathol., 2007, 35, 213-215.
[43]
Brockow, K.; Romano, A.; Blanca, M.; Ring, J.; Pichler, W.; Demoly, P. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy, 2002, 57, 45-51.
[44]
Pichler, W.J.; Daubner, B.; Kawabata, T. Drug hypersensitivity: Flare-up reactions, cross-reactivity and multiple drug hypersensitivity. J. Dermatol., 2011, 38, 216-221.
[45]
Hou, X.M.; Wu, W.Y. Toxic epidermal necrolysis after percutaneous coronary intervention: Which drug is the culprit? Chin. Med. J. (Engl.), 2011, 124, 467-468.
[46]
Harris, J.R.; Cooms, J. Tigacrelor use in a patient with documented clopidogrel hypersensitivity. Ann. Pharmacother., 2014, 48, 1230-1233.
[47]
Manchette, A.M.; Drucker, A.G.; Jannuzzi, J.L. Acute coronary syndrome antiplatelet alternatives in clopidogrel allergy. Pharmacotherapy, 2014, 34, e152-e156.
[48]
Ulman, C.A.; Palmer, D.G.; Trevino, J.J.; Olsen, T.G.; Krishnamurthy, S.; Gandhi, R.K. Acute generalized exanthematous pustulosis induced by clopidogrel. Int. J. Dermatol., 2014, 53, e461-e462.
[49]
Kaufmann, M.B.; Pham, T.; Parameswaran, L.; Choy, M. Prasugrel hypersensitivity with respiratory distress and rash. Am. J. Health Syst. Pharm., 2016, 73, 1051-1057.
[50]
Quinn, K.L.; Connelly, K.A. First report of hypersensitivity to ticagrelor. Can. J. Cardiol., 2014, 957, e3-e4.
[51]
Maybrook, R.J.; Fischer, R.; Deibert, B.; Gillihan, R.; Laarman, R.; Fraga, G.; Aires, D.; Gollub, S. Ticagrelor-induced acute generalized exanthematous pustulosis. Int. J. Cardiol., 2015, 191, 11-12.
[52]
Dai, J.; Lyu, S.; Ge, C. Hypersensitivity to ticagrelor and low response to clopidogrel: A case report. Asia Pac. Allergy, 2017, 7, 51-53.
[53]
Peppard, S.R.; Held-Googluck, B.; Beddingfield, R. Use of prasugrel in a patient with clopidigrel hypersensitivity. Ann. Pharmacother., 2011, 45, e54.
[54]
Norgard, N.B.; DiNicolantonio, J.J. Clopidogrel, prasugrel, or ticagrelor? A practical guide to use of antiplatelet agents in patients with acute coronary syndromes. Postgrad. Med., 2013, 125, 91-102.
[55]
Angiolillo, D.J.; Rollini, F. Switching from prasugrel to clopidogrel: Navigating in unknown waters. JACC Cardiovasc. Interv., 2013, 6, 166-168.
[56]
Chemnitz, J.; Sohngen, D.; Schulz, A.; Diehl, V.; Scheid, C. Fatal toxic bone marrow failure associated with clopidogrel. Eur. J. Haematol., 2003, 71, 473-474.
[57]
Mallet, L.; Mallet, J. Ticlopidine and fatal aplastic anemia in an elderly woman. Ann. Pharmacother., 1994, 28, 1169-1671.
[58]
Jacob, S.; Dunn, B.L.; Qureshi, Z.P.; Bandarenko, N.; Kwaan, H.C.; Pandey, D.K.; McKoy, J.M.; Barnato, S.E.; Winters, J.L.; Cursio, J.F.; Weiss, I.; Raife, T.J.; Carey, P.M.; Sarode, R.; Kiss, J.E.; Danielson, C.; Ortel, T.L.; Clark, W.F.; Rock, G.; Matsumoto, M.; Fujimura, Y.; Zheng, X.L.; Chen, H.; Chen, F.; Armstrong, J.M.; Raisch, D.W.; Bennett, C.L. Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: A 20-year review from the Southern Network on Adverse Reactions (SONAR). Semin. Thromb. Hemost., 2012, 38, 845-853.
[59]
Shah, R. Keough, L.A.; Belalcazar-Portacio, A.; Ramanathan, K.B. Ticagrelor as an alternative in clopidogrel-associated neutropenia. Platelets, 2015, 26, 80-82.
[60]
Beavers, C.J.; Carris, N.W.; Ruf, K.M. Management strategies for clopidogrel hypersensitivity. Drugs, 2015, 75, 999-1007.
[61]
Montalto, M.; Porto, I.; Gallo, A.; Camaioni, C.; Bona, R.D.; Grieco, A.; Crea, F.; Landolfi, R. Clopidogrel-induced neutropenia after coronary stenting: is cilostazol a good alternative? Int. J. Vasc. Med., 2011, 2011, 867964.
[62]
Lee, S.W. 1; Park, S.W.; Kim, Y.H.; Yun, S.C.; Park, D.W.; Lee, C.W.; Kang, S.J.; Park, S.J.; Lee, J.H.; Choi, S.W.; Seong, I.W.; Lee, N.H.; Cho, Y.H.; Shin, W.Y.; Lee, S.J.; Lee, S.W.; Hyon, M.S.; Bang, D.W.; Choi, Y.J.; Kim, H.S.; Lee, B.K.; Lee, K.; Park, H.K.; Park, C.B.; Lee, S.G.; Kim, M.K.; Park, K.H.; Park, W.J. Declare-long ii study investigators. A randomized, double-blind, multicenter comparison study of triple antiplatelet therapy with dual antiplatelet therapy to reduce restenosis after drug-eluting stent implantation in long coronary lesions: Results from the declare-long ii (drug-eluting stenting followed by cilostazol treatment reduces late restenosis in patients with long coronary lesions) trial. J. Am. Coll. Cardiol., 2011, 157, 1264-1270.
[63]
Lee, S.W.; Chun, K.J.; Park, S.W.; Kim, H.S.; Kim, Y.H.; Yun, S.C.; Kim, W.J.; Lee, J.Y.; Park, D.W.; Lee, C.W.; Hong, M.K.; Rhee, K.S.; Chae, J.K.; Ko, J.K.; Park, J.H.; Lee, J.H.; Choi, S.W.; Jeong, J.O.; Seong, I.W.; Jon, S.; Cho, Y.H.; Lee, N.H.; Kim, J.H.; Park, S.J. Comparison of triple antiplatelet therapy and dual antiplatelet therapy in patients at high risk of restenosis after drug-eluting stent implantation (from the declare-diabetes and -long trials). Am. J. Cardiol., 2010, 105, 168-173.
[64]
Cannon, C.P.; Gropper, S.; Bhatt, D.L.; Ellis, S.G.; Kimura, T.; Lip, G.Y.; Steg, P.G.; Ten Berg, J.M.; Manassie, J.; Kreuzer, J.; Blatchford, J.; Massaro, J.M.; Brueckmann, M.; Ferreiros Ripoll, E.; Oldgren, J. Hohnloser, S.H. design and rationale of the re-dual pci trial: a prospective, randomized, phase 3b study comparing the safety and efficacy of dual antithrombotic therapy with dabigatran etexilate versus warfarin triple therapy in patients with nonvalvular atrial fibrillation who have undergone percutaneous coronary intervention with stenting. Clin. Cardiol., 2016, 39, 555-564.
[65]
Kim, G.W.; Kang, S.Y.; Sohn, K.H.; Kim, S.H.; Cho, S.H.; Min, K.U.; Chang, Y.S. Successful sequential desensitization in a patient with drug hypersensitivity to three kinds of antiplatelet agents. Allergy Asthma Respir. Dis., 2016, 4, 374-377.
[66]
Di Chiara, A.; Chiarella, F.; Savonitto, S.; Lucci, D.; Bolognese, L.; De Servi, S.; Greco, C.; Boccanelli, A.; Zonzin, P.; Coccolini, S.; Maggioni, A.P. Epidemiology of acute myocardioal infarction in the italian ccu network: The blitz study. Eur. Heart J., 2003, 24, 1616-1629.
[67]
Kozak, L.J. 1; Lees, K.A.; DeFrances, C.J. National hospital discharge survey: 2003 annual summary with detailed diagnosis and procedure data. Vital Health Stat, 2006, 160, 1-206.
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