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Letters in Organic Chemistry

Author(s): Yang-Guo Li, Yang Zhang, Guang-Fen Du*, Cheng-Zhi Gu and Lin He*

DOI: 10.2174/1570178615666180912115748

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Phosphazene Base-Catalyzed Double Michael Addition: Stereoselective Synthesis of Cyclohexanones

Page: [76 - 80] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Phosphazene bases have been utilized as efficient organocatalysts to catalyze the double Michael additions of divinyl ketones with active methylenes to afford functionalized cyclohexanones in 36-91% yields with >25:1 diastereoselectivity.

Keywords: Phosphazene base, double Michael addition, cyclohexanone, organocatalysis, divinyl ketone, methylene.

Graphical Abstract

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