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The Natural Products Journal

Author(s): Olugbenga K. Popoola*, Francis J. Faleye, Folorunso A. Olabiyi and Olajide Ayodele

DOI: 10.2174/2210315508666180828101159

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Kinetic Behaviour of Skin Pigmentation Inhibitory Activity of some Selected Nigerian Medicinal Plants and Other Related Antioxidant Properties

Page: [280 - 288] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Background: Over exposure to Ultra Violet (UV) radiation is one of the most significant external stress-inducing factors resulting into occurrence of skin pigmentation among others in human body. The biological implication of such disorders is not only limited to premature skin aging and cancer, but also resulted into economic loss of perishable agricultural products.

Methods: Methanol extracts of ten (10) medicinal plants with skin health traditional history were selected for this study. The biological profile of the extracts was assessed in an in-vitro system using colorimetric assays: tyrosinase inhibition, Ferric-ion Reducing Antioxidant Power (FRAP), Trolox Equivalent Absorbance Capacity (TEAC) and Fe II-induced microsomal lipid peroxidation.

Results: Representative of asteraceae such as Laggera pterodonta (S3); Ageratum conyzoides (S4) and Chromolaena odorata (S5), while Euphorbia convoluloides (S8) were found to possess good anti- tyrosinase activity (IC50 = 177.50; 125.08; 167.58; 161.92) μg/ml respectively, in which the rate of formation of dopachrome proceeded via pseudo second order kinetic using the Largergren model. Other notable inhibition of oxidative stress displayed by the methanol extracts includes S7 (FRAP = 1905.12 ± 2.85 µM AAE/g); S1 & S6 (TEAC = 2163.48 ± 2.80; 1044.35 ± 28.99) µM TE/g, while S7 & S9 showed highest inhibitory activities on Fe II-induced microsomal lipid peroxidation (IC50 = 33.625; 35.125) µg/ml, respectively in competitive manner to that of the commercial anti-oxidant EGCG (IC50 = 36.250 µg/ml).

Conclusion: The outcome of the biological properties of the selected plant extracts in this study suggested the existence of relationship between the traditional claims and the scientific data therein.

Keywords: Skin pigmentation, oxidative stress, agricultural products, asteraceae, euphorbiaceae, colorimetric, kinetics, biological activities.

Graphical Abstract

[1]
Regazzetti, C.; Sormani, L.; Debayle, D.; Bernerd, F.; Tulic, M.K.; De Donatis, G.M.; Chignon-Sicard, B.; Rocchi, S.; Passeron, T. Melanocytes sense blue light and regulate pigmentation through Opsin-3. J. Invest. Dermatol., 2018, 138(1), 171-178.
[http://dx.doi.org/10.1016/j.jid.2017.07.833] [PMID: 28842328]
[2]
Kim, I.S.; Yoon, S.J.; Park, Y.J.; Lee, H.B. Inhibitory effect of ephedrannins A and B from roots of Ephedra sinica STAPF on melanogenesis. Biochim. Biophys. Acta, 2015, 1850(7), 1389-1396.
[http://dx.doi.org/10.1016/j.bbagen.2015.04.001] [PMID: 25857772]
[3]
Wangthong, S. Tonsiripakdee, l.; Monhaphol, T.; Nonthabenjawan, R.; Wanichwecharungruang, P.S. TLC developing technique for tyrosinase inhibitor detection. Biomed. Chromatogr., 2007, 21, 94-100.
[http://dx.doi.org/10.1002/bmc.727] [PMID: 17120304]
[4]
Chompoo, J.; Upadhyay, A.; Fukuta, M.; Tawata, S. Effect of Alpinia zerumbet components on antioxidant and skin diseases-related enzymes. BMC Complement. Altern. Med., 2012, 12, 106-114.
[http://dx.doi.org/10.1186/1472-6882-12-106] [PMID: 22827920]
[5]
Ferro, S.; De Luca, L.; Germanò, M.P.; Buemi, M.R.; Ielo, L.; Certo, G.; Kanteev, M.; Fishman, A.; Rapisarda, A.; Gitto, R. Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors. Eur. J. Med. Chem., 2017, 125, 992-1001.
[http://dx.doi.org/10.1016/j.ejmech.2016.10.030] [PMID: 27810600]
[6]
Chang, T.S. An updated review of tyrosinase inhibitors. Int. J. Mol. Sci., 2009, 10(6), 2440-2475.
[http://dx.doi.org/10.3390/ijms10062440] [PMID: 19582213]
[7]
Summers, B. A lightening tour of skin-brightening options. Pharm. Cosmetic Rev., 2006, 33(6), 29-33.
[8]
Mapunya, M.B.; Nikolova, R.V.; Lall, N. Melanogenesis and antityrosinase activity of selected South African plants. Evid. Based Complement. Alternat. Med., 2012, 2012374017
[http://dx.doi.org/10.1155/2012/374017] [PMID: 22611429]
[9]
Kim, M.; Shin, S.; Lee, J.A.; Park, D.; Lee, J.; Jung, E. Inhibition of melanogenesis by Gaillardia aristata flower extract. BMC Complement. Altern. Med., 2015, 15, 449.
[http://dx.doi.org/10.1186/s12906-015-0972-1] [PMID: 26702819]
[10]
Fuyuno, I. Spotlight turns on cosmetics for Asian skin. Nature, 2004, 432(7020), 938-1038.
[http://dx.doi.org/10.1038/432938a] [PMID: 15616523]
[11]
Curto, E.V.; Kwong, C.; Hermersdörfer, H.; Glatt, H.; Santis, C.; Virador, V.; Hearing, V.J.; Dooley, T.P. Inhibitors of mammalian melanocyte tyrosinase: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors. Biochem. Pharmacol., 1999, 57(6), 663-672.
[http://dx.doi.org/10.1016/S0006-2952(98)00340-2] [PMID: 10037452]
[12]
Parvez, S.; Kang, M.; Chung, H.S.; Cho, C.; Hong, M.C.; Shin, M.K.; Bae, H. Survey and mechanism of skin depigmenting and lightening agents. Phytother. Res., 2006, 20(11), 921-934.
[http://dx.doi.org/10.1002/ptr.1954] [PMID: 16841367]
[13]
Hermanns, J.F.; Piérard-Franchimont, C.; Piérard, G.E. Skin colour assessment in safety testing of cosmetics. An overview. Int. J. Cosmet. Sci., 2000, 22(1), 67-71.
[http://dx.doi.org/10.1046/j.1467-2494.2000.00021.x] [PMID: 18503462]
[14]
Biswas, R.; Mukherjee, P.K.; Dalai, M.K.; Mandal, P.K. Tyrosinase inhibitory potential of purpurin in Rubia cordifolia. A bioactivity guided approach. Ind. Crops Prod., 2015, 74, 319-326.
[http://dx.doi.org/10.1016/j.indcrop.2015.04.066]
[15]
Moon, J.Y.; Yim, E.Y.; Song, G.; Lee, N.H.; Hyun, C.G. Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants. Eur. Asian J. Biosci., 2010, 4, 41-53.
[http://dx.doi.org/10.5053/ejobios.2010.4.0.6]
[16]
Huang, X.H.; Chen, Q.X.; Wang, Q.; Song, K.K.; Wang, J.; Sha, L.; Guan, X. Inhibition of the activity of mushroom tyrosinase by alkylbenzoic acids. Food Chem., 2006, 94, 1-6.
[http://dx.doi.org/10.1016/j.foodchem.2004.09.008]
[17]
Pang, Y.; Wang, D.; Fan, Z.; Chen, X.; Yu, F.; Hu, X.; Wang, K.; Yuan, L. Blumea balsamifera-a phytochemical and pharmacological review. Molecules, 2014, 19(7), 9453-9477.
[http://dx.doi.org/10.3390/molecules19079453] [PMID: 24995927]
[18]
Popoola, O.K.; Marnewick, J.L.; Rautenbach, F.; Ameer, F.; Iwuoha, E.I.; Hussein, A.A. Inhibition of oxidative stress and skin aging-related enzymes by prenylated chalcones and other flavonoids from Helichrysum teretifolium. Molecules, 2015, 20(4), 7143-7155.
[http://dx.doi.org/10.3390/molecules20047143] [PMID: 25903365]
[19]
Ahmadu, A.A.; Tarimaledei, P.; Onanuga, A. Triterpenoids from Gutenbergia nigritana (Benth). Oliv and Hiern. Afr. J. Tradit. Complement. Altern. Med., 2013, 10(3), 405-409.
[http://dx.doi.org/10.4314/ajtcam.v10i3.3] [PMID: 24146466]
[20]
Adetutu, A.; Olorunnisola, O.S.; Oyewo, E.B. Phytochemical composition, antioxidant properties and antibacterial activities of five West-African green leafy vegetables. Canadian J. Pure App. Sci., 2013, 7, 2357-2362.
[21]
Owoeye, O.; Arinola, G.O.A. Vegetable, Launaea taraxacifolia, mitigated mercuric chloride alteration of the microanatomy of rat brain. J. Diet. Suppl., 2017, 14(6), 613-625.
[http://dx.doi.org/10.1080/19390211.2017.1288194] [PMID: 28471730]
[22]
Donkor, A.M.; Oduro-Mensah, D.; Fiazorh, M. Extracts of Euphobia hirta Linn and Physalis angulata L. and their amalgamation demonstrate potency against Staphylococcus aureus and Pseudomonas aeruginosa. Int. J. Pharm. Pharm. Sci., 2016, 8, 322-326.
[23]
Iloki-Assanga, S.B.; Lewis-Luján, L.M.; Lara-Espinoza, C.L.; Gil-Salido, A.A.; Fernandez-Angulo, D.; Rubio-Pino, J.L.; Haines, D.D. Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum. BMC Res. Notes, 2015, 8, 396.
[http://dx.doi.org/10.1186/s13104-015-1388-1] [PMID: 26323940]
[24]
Vardhan, A.K.; Pandey, B. Screening of plant parts for anti-tyrosinase activity by tyrosinase assay using mushroom tyrosinase. Indian J. Soc. Res., 2014, 4, 134-139.
[25]
Benzie, I.F.F.; Strain, J.J. The Ferric Reducing Ability of Plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay. Anal. Biochem., 1996, 239(1), 70-76.
[http://dx.doi.org/10.1006/abio.1996.0292] [PMID: 8660627]
[26]
Pellegrini, N.; Re, R.; Yang, M.; Rice-Evans, C.A. Screening of dietary carotenoid rich fruit extracts for antioxidant activities applying ABTS radical cation decolorisation assay. Methods Enzymol., 1999, 299, 379-389.
[http://dx.doi.org/10.1016/S0076-6879(99)99037-7]
[27]
Snijman, P.W.; Joubert, E.; Ferreira, D.; Li, X.C.; Ding, Y.; Green, I.R.; Gelderblom, W.C.A. Antioxidant activity of the dihydrochalcones Aspalathin and Nothofagin and their corresponding flavones in relation to other Rooibos (Aspalathus linearis) Flavonoids, Epigallocatechin Gallate, and Trolox. J. Agric. Food Chem., 2009, 57(15), 6678-6684.
[http://dx.doi.org/10.1021/jf901417k] [PMID: 19722573]
[28]
Ho, Y.S.; McKay, G. The sorption of Pb(II) ions on peat. Water Res., 1999, 33, 578-584.
[http://dx.doi.org/10.1016/S0043-1354(98)00207-3]
[29]
Demirbas, E.; Kobya, M.; Senturk, E.; Ozkan, T. Adsorption kinetics for the removal of chromium (VI) from aqueous solutions on the activated carbons prepared from agricultural wastes. 2004, 30, 533-539.
[http://dx.doi.org/10.4314/wsa.v30i4.5106]
[30]
Sivakami, M.S.; Gomathi, T.; Venkatesan, J.; Jeong, H.S.; Kim, S.K.; Sudha, P.N. Preparation and characterization of nano chitosan for treatment wastewaters. Int. J. Biol. Macromol., 2013, 57, 204-212.
[http://dx.doi.org/10.1016/j.ijbiomac.2013.03.005] [PMID: 23500442]
[31]
Méité, S.I.; Bagré, B.; Bahi, G.; N’guessan, J.D.; Djaman, A.J. Antioxidant activity of water extract of Mareya micrantha (Benth.) Mull. Arg. (Euphorbiaceae). Eur. J. Biomed. Pharm. Sci., 2017, 4, 5-11.
[32]
Satya, P.M.; Suman, J.; Narendra, K.; Srinivas, K.; Srilakshmi, B.J.; Lakshmi, C.M.; Krishma, S.A. Phytochemical and pharmacological evaluation of Euphorbiaceae family plant leaves-Acalypha indica L., Croton bonplandianum Baill. Mintage J. Pharm. Med. Sci., 2015, 4, 17-22.
[33]
Ravi, S.; Shanmugam, B.; Subbaiah, G.V.; Prasad, S.H.; Reddy, K.S. Identification of food preservative, stress relief compounds by GC-MS and HR-LC/Q-TOF/MS; evaluation of antioxidant activity of Acalypha indica leaves methanolic extract (in vitro) and polyphenolic fraction (in vivo). J. Food Sci. Technol., 2017, 54(6), 1585-1596.
[http://dx.doi.org/10.1007/s13197-017-2590-z] [PMID: 28559618]
[34]
Anokwuru, C.P.; Sinisi, A.; Samie, A.; Taglialatela-Scafati, O. Antibacterial and antioxidant constituents of Acalypha wilkesiana. Nat. Prod. Res., 2015, 29(12), 1180-1183.
[http://dx.doi.org/10.1080/14786419.2014.983105] [PMID: 25426700]
[35]
Udobang, J.A.; Nwafor, P.A.; Okokon, J.E. Analgesic and antimalarial activities of crude leaf extract and fractions of Acalypha wilkensiana. J. Ethnopharmacol., 2010, 127(2), 373-378.
[http://dx.doi.org/10.1016/j.jep.2009.10.028] [PMID: 19892007]
[36]
Ma, Q.; Wei, R.; Liu, W.; Sang, Z.; Guo, X. Cytotoxic anthraquinones from the aerial parts of Acalypha australis. Chem. Nat. Compd., 2017, 53, 949-952.
[http://dx.doi.org/10.1007/s10600-017-2165-2]
[37]
Jemli, E.I.; Kamal, R.; Marmouzi, I.; Zerrouki, A.; Cherrah, Y.; Alaoui, K. Radical scavenging activity and ferric reducing ability of Junniperus thurifera (L.); J. oxycedrus (L.); J. phoenicea (L.); and Tetraclinis articulata (L.). Adv. Pharm. Sci., 2016, 2016 Article ID 6392656
[38]
Ko, H.H.; Chang, W.L.; Lu, T.M. Antityrosinase and antioxidant effects of ent-kaurane diterpenes from leaves of Broussonetia papyrifera. J. Nat. Prod., 2008, 71(11), 1930-1933.
[http://dx.doi.org/10.1021/np800564z] [PMID: 18986201]
[39]
Baurin, N.; Arnoult, E.; Scior, T.; Do, Q.T.; Bernard, P. Preliminary screening of some tropical plants for anti-tyrosinase activity. J. Ethnopharmacol., 2002, 82(2-3), 155-158.
[http://dx.doi.org/10.1016/S0378-8741(02)00174-5] [PMID: 12241990]
[40]
Kim, Y.J.; Uyama, H. Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cell. Mol. Life Sci., 2005, 62(15), 1707-1723.
[http://dx.doi.org/10.1007/s00018-005-5054-y] [PMID: 15968468]