Abstract

Background: A highly efficient eco-friendly route for the synthesis of pyrazole derivatives from readily available chalcones/1, 3-diketones and hydrazines in glycerol using sarcosine as a novel organopromoter has been developed. To the best of our knowledge this is the first report on the use of sarcosine as an organocatalyst in organic transformations.

Results and Methods: This method manifests several attributes of green chemistry like atomeconomy, reusability of catalyst, short reaction time and an eco-friendly medium.

Conclusion: The present protocol can serve as a valuable green alternative to the existing methods for the synthesis of targeted molecules.

Keywords: Catalysis, glycerol, green synthesis, pyrazole, sarcosine.

Graphical Abstract