Abstract

Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.

Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.

Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.

Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.

Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.

Keywords: Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins, neural tissue.

Graphical Abstract