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Current Bioinformatics

Author(s): Kai-jian Xia*, Jian-qiang Wang and Jian Cai

DOI: 10.2174/1574893613666180704153946

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A Novel Adaptive PET/CT Image Fusion Algorithm

Page: [658 - 666] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Background: Lung cancer is one of the common malignant tumors. The successful diagnosis of lung cancer depends on the accuracy of the image obtained from medical imaging modalities.

Objective: The fusion of CT and PET is combining the complimentary and redundant information both images and can increase the ease of perception. Since the existing fusion method sare not perfect enough, and the fusion effect remains to be improved, the paper proposes a novel method called adaptive PET/CT fusion for lung cancer in Piella framework.

Methods: This algorithm firstly adopted the DTCWT to decompose the PET and CT images into different components, respectively. In accordance with the characteristics of low-frequency and high-frequency components and the features of PET and CT image, 5 membership functions are used as a combination method so as to determine the fusion weight for low-frequency components. In order to fuse different high-frequency components, we select the energy difference of decomposition coefficients as the match measure, and the local energy as the activity measure; in addition, the decision factor is also determined for the high-frequency components.

Results: The proposed method is compared with some of the pixel-level spatial domain image fusion algorithms. The experimental results show that our proposed algorithm is feasible and effective.

Conclusion: Our proposed algorithm can better retain and protrude the lesions edge information and the texture information of lesions in the image fusion.

Keywords: Lung cancer, PET/CT fusion, Piella framework, membership functions, DTCWT, activity measure, decision factor.

Graphical Abstract

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