An Overview on Analytical Methods for Quantitative Determination of Aristolochic Acids

Mohammad-Reza       Afshar-Mogaddam; Adeleh			      Yadeghari; Abolghasem			      Jouyban
Abstract

Background: Aristolochic acids are chemically linked to nitrophenanthrene carboxylic acids which are found in aristolochia plants. These compounds are intrinsically carcinogenic, while they have been used in traditional medicine from a long time ago. Despite the beneficial effects of herbals for treating some diseases, they possess some side effects.
Methods: Therefore, the development of a sensitive and selective procedure for the determination of these harmful components in various complicated samples is an important task for health systems and drug authorities. In the past years, ultra-pressure liquid chromatography, high performance liquid chromatography and capillary electrophoresis with different detection systems were used for determination of aristolochic acids in various samples.
Results: In this review, different analytical methods have been discussed in brief and applications of them in diverse samples have been summarized.
Conclusion: Different approaches are compared from point of sensitivity, selectivity, and extraction efficiency.
Keywords: Aristolochic acids, capillary electrophoresis, high-performance liquid chromatography, sample preparation, ultraperformance liquid chromatography, review.
Graphical Abstract

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Cite As
Current Analytical Chemistry

An Overview on Analytical Methods for Quantitative Determination of Aristolochic Acids

Abstract

Graphical Abstract
