Abstract

Intoduction: A highly efficient protocol for the one pot synthesis of 4(3H)-quinazolinones from anthranilic acid, ortho esters and various amines using a magnetically separable solid acid catalyst, nano sulfated TiO2 encapsulated Fe3O4 with microwave irradiation, is described. The plausible reaction mechanism for the synthesis of 4(3H)-quinazolinone, catalyzed by sulfated TiO2 encapsulated magnetic nanomaterial is also described.

Conclusion: The developed process has been successfully applied for the synthesis of diverse 4(3H)- quinazolinones with variable functionality. This approach overcomes many of the drawbacks of the existing methods and provides an environmentally benign process.

Keywords: Magnetic nanoparticles, nano sulfated TiO2, solid acid catalyst, quinazolinone, microwave, amines.

Graphical Abstract