Abstract

A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A4 hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.

Keywords: hydroxamic acids, arthritis, matrix metalloproteinases, lipoxigenases, peptide deformilases, succiny1 hydroxamates, angiotensin converting enzyme, zinc metalloenzyme, inflammatory response, helicobacter pylori