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Letters in Organic Chemistry

Author(s): Ravi Lakkakula, K. Mukkanti and Arnab Roy*

DOI: 10.2174/1570178615666180518090406

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An Efficient and Straightforward Total Synthesis of (±)-Preclamol

Page: [1065 - 1069] Pages: 5

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Abstract

A prudent and scalable synthesis of (±)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-α-carbethoxy acetonitrile derivative as a key step.

Keywords: Michael addition, in-situ reduction/cyclization, preclamol, risperidone, alogliptin, ritalin.