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Current Bioactive Compounds

Author(s): Vasant Chabukswar*, Digamber Pawar, Kalpana Handore, Suresh Shisodia, Balasaheb Diwate, Pravin Adhav, Swati Jagdale, Anuruddha Chabukswar, Vishwas Gaikwad and Sabrina Dallavalle

DOI: 10.2174/1573407214666180503114844

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Biopolymer Catalysed Synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4- Tetrahydropyrimidine-2-ones and Evaluation of their Anti-bacterial and Anti-tubercular Activities

Page: [408 - 414] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Background: An efficient one-pot biocatalysed ultrasound assisted synthesis of dihydropyrimidinones/ thiones has been developed under solvent free conditions.

Materials and Methods: The use of biodegradable, non toxic, agar-powder as a catalyst provide advantages like high yield, simple operation, mild reaction condition with short reaction time. 1,2,3,4- tetrahydropyrimidine-2-ones/thiones formed were characterized by mass and 1H NMR spectroscopy.

Results: The dihydropyrimidinones substituted with electron donating groups like fluorine, hydroxy along with thienyl groups exhibited good antibacterial activity. The compounds exhibited favorable binding interactions with mycobacterium target protein H37Rv.

Conclusion: 4-methoxy substituted dihydropyrimidinones derivative showed significant antituberculosis activity.

Keywords: Biocatalysed synthesis, solvent free, green chemistry, antibacterial activity, anti tubercular activity, carambine.

Graphical Abstract

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