Abstract
Objective: Ozenoxacin is one of the potent quinolone antibiotics, recently approved by the
United States Food and Drug Administration (USFDA) with reported pharmacology to treat the
impetigo. The demand for better acting topical formulation is increasing day by day. The present review
is an attempt to summarize the facts behind the chemistry and biological applications of Ozenoxacin.
Mechanism of Action: This novel drug being a quinolone antibiotic compound, acts by inhibiting DNA
gyrase A and topoisomerase IV and affects supercoiling, supercoil relaxation, chromosomal
condensation, chromosomal decatenation and many others.
Pharmacology: Ozenoxacin has demonstrated to have a bactericidal activity against organisms, such as
Staphylococcus aureus and Staphylococcus pyogenes. Ozenoxacin is non-fluorinated quinolone and
being developed for the other dermatological bacterial infections as well. No sign of genotoxicity was
observed when tested experimentally.
Conclusion: The present review also covers the complete picture of pharmacokinetics, clinical trials,
toxicity and future scope and possible avenues in this arena.
Keywords:
Impetigo, Ozenoxacin, Staphylococcus aureus, Staphylococcus pyogenes, quinolone antibiotic, drug discovery.
Graphical Abstract
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