Abstract

Propargylamines are prominent components strikethrough as precursors for the synthesis of miscellaneous nitrogen-containing compounds, such as allylamines, pyrrolidines, pyrroles and oxazoles or as intermediates in the preparation of a various natural product, biologically active and pharmaceutical compounds. The catalytic coupling of the aldehyde–alkyne–amine (A3 coupling) has shown great utility in the simple and rapid preparation of propargylamines in broadly tolerant and highly tunable reaction conditions. In this respect, various catalytic systems using transition metal catalysts have been developed. Based on a literature survey, Cu catalysts have promoted this field substantially via development of new methods for the synthesis of propargylamines. This review will cover copper-based catalyst system reported for the synthesis of propargylamine derivatives until 2017.

Keywords: Multicomponent Reactions, propargylamine, A3 coupling, copper-based catalyst, bulk catalyst, nanocatalysts.