Abstract

Background: Progesterone is a sex steroid hormone. Since it has been discovered, it is widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions.

Methods: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditional preparations up through the very recent literatures.

Results: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations.

Conclusion: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can be greatly increased.

Keywords: Delivery system, injection, microspheres, oral, progesterone preparations, vaginal.

Graphical Abstract