Abstract

This work describes an efficient and new catalyst for the one-pot synthesis of organic disulfides/ sulfides via a palladium catalyst in the presence of PPh3 ligands for domino cross-coupling reaction of aryl halides and thiourea and then sulfur-transformation. Finally, the generated aryl thiolate converts to disulfide at normal oxidative and atmospheric conditions in DMF/water. However, thiols convert to unsymmetrical sulfides by one-pot reaction with alkyl halides in PEG/H2O.

Keywords: Palladium catalyst, organic disulfides/sulfides, cross-coupling reaction, thiourea, K2PdCl4, halides.

Graphical Abstract