Author(s): Lauren A. Thurlow, Khalyd J. Clay, Taylor P. Wene, Meg L. Groom, Erin S. Keyes, Alexis D. Lang and Jeremy E.B. McCallum*
Page: [909 - 914] Pages: 6
* (Excluding Mailing and Handling)
Achiral N9-benzylguanine derivatives with alkene moieties attached to the benzyl group were synthesized with the intent of targeting a covalently linked unimolecular quadruplex using olefin cross-metathesis. Three N9-(3,5-bis(alkenyloxy)benzyl)-guanine derivatives were synthesized and shown to form stable G-quartet structures in the presence of a central cation. Upon the addition of K+, the guanine derivative, N9-(3,5-Bis(pent-4-en-1-yloxy)benzyl)-guanine, self-assembled into a discrete [G]12-dodecamer quadruplex structure.
Keywords: Guanine, benzylguanine, DNA, dodecamer, G-quartet, G-quadruplex.
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