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Current Medicinal Chemistry

Author(s): Enrico Faggi, Santiago V. Luis and Ignacio Alfonso*

DOI: 10.2174/0929867325666180301091040

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Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides

Page: [4065 - 4097] Pages: 33

  • * (Excluding Mailing and Handling)

Abstract

Pseudopeptides are privileged synthetic molecules built from the designed combination of peptide-like and abiotic artificial moieties. Consequently, they are benefited from the advantages of both families of chemical structures: modular synthesis, chemical and functional diversity, tailored three-dimensional structure, usually high stability in biological media and low non-specific toxicity. Accordingly, in the last years, these compounds have been used for different biomedical applications, ranging from bio-sensing, ion transport, the molecular recognition of biologically relevant species, drug delivery or gene transfection. This review highlights a selection of the most remarkable and recent advances in this field.

Keywords: Pseudopeptides, sensing, transport, cation coordination, anion coordination, gene delivery.

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