Abstract

The growing evidence shows that LIM and SH3 Domain Protein 1 (LASP1) is a multi-functional protein that plays important role in forming cytoskeleton and prognostic marker in different cancers. LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. And the upregulation of LASP1 facilitates tumor cells proliferation, migration, and invasion perhaps through the interaction with cytoskeleton and increased nuclear translocation. The underlying mechanism of LASP1 on tumor is still in the initial stage; therefore, the signaling pathways in various tumors are specifically summarized to deepen the biological understanding of LASP1. This article systematically summarizes the current status of knowledge regarding the contribution of LASP1 in physiological and pathological processes, especially the progress in tumor. This article also gives an emphasized overview of LASP1 on the correlation with tumor microenvironment.

Keywords: LIM and SH3 domain protein 1, tumor microenvironment, oncogene, metastasis, nucleus translocation, cytoskeleton.