[1]
Tomita, K.; Tsuzuki, Y.; Shibamori, K.; Tashima, M.; Kajikawa, F.; Sato, Y.; Kashimoto, S.; Chiba, K.; Hino, K. Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1. J. Med. Chem., 2002, 45, 5564-5575.
[2]
Kaizerman, J.; Lucas, B.; McMinn, D.; Zmboni, R. Pyridopyridazine
compounds, compositions and methods of use.
US0099173 A1, 2009.
[3]
Kaizerman, J.A.; Aaron, W.; An, S.; Austin, R.; Brown, M.; Chong, A.; Lee, G. Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines. Bioorg. Med. Chem. Lett., 2010, 20(15), 4607-4610.
[4]
Bold, G.; Altmann, K.H.; Frei, J.; Lang, M.; Manley, P.W.; Traxler, P.; Wietfeld, B.; Brüggen, J.; Buchdunger, E.; Cozens, R.; Ferrari, S.; Furet, P.; Hofmann, F.; Martiny-Baron, G.; Mestan, J.; Rösel, J.; Sills, M.; Stover, D.; Acemoglu, F.; Boss, E.; Emmenegger, R.; Lässer, L.; Masso, E.; Roth, R.; Schlachter, C.; Vetterli, W.; Wyss, D.; Wood, J.M. New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J. Med. Chem., 2000, 43, 2310-2323.
[5]
Kumar, V.; Sanna, V.K.; Singh, A.T.; Jaggi, M.; Sharma, P.K.; Irchhaiya, R.; Burman, A.C. Synthesis and anti-cancer activity of pyrido[2,3-c]pyridazine derivatives. J. Sci. Islam. Repub. Iran, 2009, 20, 325-329.
[6]
El-Sharkawy, K.A.; Ibrahim, R.A. New approaches for the synthesis and antitumor evaluation of pyridine, thieno[3,4-c]pyridine, pyrazolo[3,4-b]pyridine and pyrido[3,4-d]pyridazine derivatives. Eur. Chem. Bull., 2013, 2(8), 530-537.
[7]
Cobo, J.; Sanchez, A.; Nougueras, M. Synthesis and antiviral evaluation of pyridine fused heterocyclic and nucleosidic derivatives. Tetrahedron, 1997, 53, 8225-8236.
[8]
Miyamoto, T.; Matsumoto, J. Fluorinated pyrido [2, 3-c]pyridazines. ii. synthesis and antibacterial activity of 1, 7-disubstituted 6-fluoro-4 (1h)-oxopyrido [2, 3-c]pyridazine-3-carboxylic acids. Chem. Pharm. Bull., 1990, 38, 3359-3365.
[9]
Stanasiuk, J. Investigations on the synthesis and properties of 2-(alkyl,aryl)-1,4,5-trioxo-1,2,3,4,5,6-hexahydropyrido[3,4-d]pyrida-zines, derivatives with potential biological activity. Acta Pol. Pharm., 2006, 63, 420-421.
[10]
Fadda, A.A.; Rabie, R.R.; Bondock, S.; Etman, H.A. Derivational, structural, and biological studies of some new pyrazolyl, isoxazolyl, pyrimidynyl, pyridazinyl, and pyridopyridazinyl from 4-substituted antipyrine. J. Heterocycl. Chem., 2017, 54(2), 1304-1310.
[11]
Elassar, A.Z.A. Synthesis and antimicrobial activity of new polyfunctionally substituted pyridines and their fused derivatives. Indian J. Chem., 2004, 43B, 1314-1319.
[12]
Sladowska, H.; Filipek, B.; Sapa, J.; Sieklucka-Dziuba, M.; Szymanska, M.; Kleinrok, Z.; Sokolowska, M. Synthesis and properties of tetra(hexa)hydropyrazolo[1,2-a]pyrido-[3,4]pyridazine derivatives. Boll. Chim. Farm., 2003, 142(1), 21-27.
[13]
Sladowska, H.; Potoczek, J.; Sieklucka-Dziuba, M.; Rajtar, G.; Mlynarczyk, M.; Kleinrok, Z. Investigations on the synthesis and properties of some N-arylpiperazinylalkyl derivatives of 1,4-dioxo(1,4,5-trioxo)-1,2,3,4-tetra (and 1,2,3,4,5,6-hexa)hydro-pyrido[3,4-d]pyridazines. Farmaco, 1995, 50, 37-46.
[14]
Sladowska, H.; Bodetko, M.; Sieklucka-Dziuba, M.; Rajtar, G.; Zolkowska, D.; Kleinrok, Z. Transformation of some pyrido[2,3-d]pyrimidine derivatives into other di- and triheterocyclic systems. Farmaco, 1997, 52, 657-662.
[15]
Sladowska, H.; Potoczek, J.; Sokolowska, M.; Rajtar, G.; Sieklucka-Dziuba, M.; Kocki, T.; Kleinrok, Z. Investigations on the synthesis and properties of N-phenyl derivatives of 1,4-dioxo(1,4,5-trioxo)-1,2,3,4-tetra(1,2,3,4,5,6-hexa)hydropyrido[3,4-d]pyridazines and allied compounds. Farmaco, 1998, 53, 468-474.
[16]
Sladowska, H.; Stanasiuk, J.; Sieklucka-Dziuba, M.; Saran, T.; Kleinrok, Z. Investigatios on the synthesis and properties of 4-aminosubstituted 2,6,7-trimethyl-1,5-dioxo-1,2,5,6-tetrahydro-pyri-do[3,4-d]pyridazines. Farmaco, 1998, 53, 475-479.
[17]
Sladowska, H.; Potoczek, J.; Rajtar, G.; Sieklucka-Dziuba, M.; Mlynarczyk, M.; Kleinrok, Z. Synthesis and pharmacological evaluation of N-aryl(pyrimidinyl)piperazinylalkyl (hydroksyalkyl) derivatives of 1,2,3,4-tetra- and 1,2,3,4,5,6-hexahydropyrido[3,4-d]pyridazines. Farmaco, 1996, 51, 431-436.
[18]
Pakulska, W.; Malinowski, Z.; Szcześniak, A.K.; Czarnecka, E.; Epsztajn, J. Synthesis and pharmacological evaluation of N-(Dimethylamino)ethyl derivatives of benzo- and pyridopyriazinones. Arch. Pharm. Chem. Life Sci, 2009, 342, 41-47.
[19]
Mitchinson, A.; Blackaby, W.P.; Bourrain, S.; Carling, R.W.; Lewis, R.T. Synthesis of pyrido [2, 3-d] pyridazines and pyrazino [2, 3-d]pyridazines-novel classes of GABA a receptor benzodiazepine binding site ligands. Tetrahedron Lett., 2006, 47, 2257-2260.
[20]
Goodacre, S.C.; Hallett, D.J. Substituted pyrido-pyridazine derivatives
which enhance cognition via the Gaba-a receptors.
US7148222 2006.
[21]
Dong, Z.Q.; Liu, X.M.; Wei, C.X.; Quan, Z.S. Design, synthesis of 6-substituted-pyrido[3,2-d]pyridazine derivatives with anticonvulsant activity. Med. Chem., 2015, 11(6), 595-601.
[22]
Gößnitzer, E.; Krbavcic, A.; Wendelin, W.; Krbavcic, M. Synthesis and structure investigations of potential sedative and anticonvulsant hydroxy-and acetoxy-N-(3-oxobutyl)-pyrido [2, 3-d]pyridazinones. Monatsh. Chem., 2002, 133(9), 1177-1185.
[23]
Oka, Y.; Itoh, K.; Miyake, A.; Tada, N.; Omura, K.; Tomimoto, M.; Yurugi, S. Studies on the syntheses of N-Heterocyclic compounds. XXVI. Syntheses of pyrido[3,4-d]pyridazine derivatives (3). Chem. Pharm. Bull., 1975, 23(10), 2306-2317.
[24]
Oka, Y.; Omura, K.; Miyake, A.; Itoh, K.; Tomimoto, M.; Tada, N.; Yurugi, S. Studies on the syntheses of N-Heterocyclic compounds. XXV. Syntheses of pyrido[3,4-d]pyridazine derivatives (2). Chem. Pharm. Bull., 1975, 23(10), 2239-2250.
[25]
Omura, K.; Tada, N.; Tomimoto, M.; Usui, Y.; Oka, Y.; Yurugi, S. Studies on the syntheses of N-heterocyclic compounds. XXVIII. Syntheses of pyrido[3,4-d]pyridazine derivatives (4). Chem. Pharm. Bull., 1976, 24(11), 2699-2710.
[26]
Yu, G.; Mason, H.; Wu, X.; Wang, J.; Chong, S.; Beyer, B.; Henwood, A.; Pongrac, R.; Seliger, L.; He, B.; Normandin, D.; Ferrer, P.; Zhang, R.; Adam, L.; Humphrey, W.G.; Krupinski, J.; Macor, J.E. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: Potential agents for treatment of erectile dysfunction. J. Med. Chem., 2003, 46, 457-460.
[27]
Dal Piaz, V.; Giovannoni, M.P.; Castellana, C. Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. J. Med. Chem., 1997, 40, 1417-1421.
[28]
Dal Piaz, V.; Giovannoni, M.P.; Castellana, C.; Palacios, J.M.; Beleta, J.; Domenech, T.; Segarra, V. Heterocyclic-fused 3(2H)-pyridazinones as potent and selective PDE IV inhibitors: Further structure-activity relationships and molecular modelling studies. Eur. J. Med. Chem., 1998, 33, 789-797.
[29]
Pita, B.; Sotelo, E.; Suárez, M.; Raviña, E.; Ochoa, E.; Verdecia, Y.; Peeters, O.M. Pyridazine derivatives. Part 21: Synthesis and structural study of novel 4-aryl-2, 5-dioxo-8-phenylpyrido [2, 3-d]pyridazines. Tetrahedron, 2000, 56(16), 2473-2479.
[30]
Abdelrazek, F.M.; El-Din, A.; Fathyb, M. A novel synthesis and molluscicidal activity of some functionally substituted pyridine, pyrido[3,2-c]pyridazine, and pyrido[3,2-c]pyridazino[2,3-a]quina-zoline derivatives. Arch. Pharm. Chem. Life Sci, 2005, 338, 329-334.
Download PDF Flyer