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Letters in Organic Chemistry

Author(s): Manijeh Nematpour*, Elham Abedi and Elahe Abedi

DOI: 10.2174/1570178615666171222162430

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A Direct Access to N-Arylation of Guanidines by Ligand-Free, Copper Catalysis at Room Temperature

Page: [678 - 681] Pages: 4

  • * (Excluding Mailing and Handling)

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Abstract

The copper (I)-catalyzed cross-coupling reactions between aryl halides and guanidines to produce N-aryl guanidines have been developed. Mild reaction conditions, good yields, ligand-free, easy work-up, no column chromatography, and ease of handling at room temperature are the main aspects of the method.

Keywords: N-Arylation, ullmann coupling, guanidine, copper-catalyzed, aryl halides, organic.

Graphical Abstract