Synthesis of Hitherto Unknown 4,4-Bis(methylthio)but-3-en-2-one-1,1,1,3- d4 and Its Application as 1,3-Dielectrophilic Building Block for the Synthesis of Deuterated Heterocycles and Aromatics

T.P.       Charanraj; P.       Ramachandra; N.       Ramesh; H.       Junjappa

Letters in Organic Chemistry

Author(s): T.P. Charanraj, P. Ramachandra, N. Ramesh and H. Junjappa*

DOI: 10.2174/1570178615666171205095718

Download PDF Flyer Cite As

Synthesis of Hitherto Unknown 4,4-Bis(methylthio)but-3-en-2-one-1,1,1,3- d4 and Its Application as 1,3-Dielectrophilic Building Block for the Synthesis of Deuterated Heterocycles and Aromatics

Page: [412 - 417] Pages: 6

* (Excluding Mailing and Handling)

Abstract

Acetone-d6 has been transformed for the first time to 4,4-bis(methylthio)but-3-en-2-one- 1,1,1,3-d4. This tetradeutero-α-oxoketenedithioacetal is shown to be an excellent 1,3-dielectrophilic building block for the synthesis of 5- and 6-membered deuterated heterocycles and aromatics.

Keywords: Acetone-d6, α-oxoketenedithioacetal, 1, 3-dielectrophilic building block, deuterated heterocycles, aromatics, aromatic compounds.

Graphical Abstract

Cite As