Abstract

In the present study a series of metal complex of [bis (2-amino-5-aryl-1,3,4-thiadiazole]2Cl (S1-S9) was synthesized by using ultrasound irradiation technique. The metal complex was synthesized by the reaction between ligand and appropriate metal salts (CuCl2. 2H2O, CoCl2. 6H2O, ZnCl2, MgCl2. 4H2O, NiCl2. 6H2O). The products were obtained in high yield and the reaction time was found to be shorter. The synthesized metal complexes were characterized by using UV-visible spectroscopy, FTIR, 1H NMR and Mass spectroscopy. The synthesized compounds were investigated for antibacterial potential against gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) and gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli). Significant activity was observed for synthesized metal complexes S6 and S7 against B. subtilis and S. aureus.

Keywords: Antibacterial activity, green chemistry, 1, 3, 4-thiadiazole, sonochemistry, regional, metal salt.

Graphical Abstract