Abstract

Background: Pharmaceutical industry is one of the most popular sectors known for spreading of pollution. Here the association with various bases belonging to either organic or inorganic for the enhancement of different transformation is a routine practice for manufacturing of active pharmaceutical ingredients and their intermediates. This results in the destruction of environment directly or indirectly because such bases are non-recoverable and non-recyclable.

Methods: Present investigation has focused on the advantage of application of century old hydrotalcite as a green catalyst, which is recoverable and recyclable, in various organic transformations useful for the synthesis of some active pharmaceutical ingredients and their intermediates. Here the authors have identified research gap and disclosed novel green synthetic procedures catalyzed by hydrotalcite. Hydrolysis, oxidation, S-Alkylation, Knovengel condensation and peptide bonding transformations were tested in this protocol resulting in efficient, cost effective, eco-benign and industrially advantageous outcome.

Conclusion: This methodology was assessed by Reaction Mass Efficiency, one of the green metrics, proving it to be eco-friendly as well as describing its financial importance which comes under green and sustainable practices.

Keywords: Clay, green chemistry, hydrotalcite, organic transformations, reaction mass efficiency, sustainable procedures.

Graphical Abstract