Abstract

Background: Many methods have been reported for the determination of ceftazidime such as liquid chromatography, spectrophotometry and electrochemical methods. Among these methods, electrochemical methods have their unique advantages such as rapidity, low cost and simplicity.

Methods: In this work, electrochemical technique was used for the determination of ceftazidime using a carbon nanotube modified electrode. Sodium dodecyl benzene sulphonate (SDBS) was used to enhance the electrochemical response. Experimental parameters including accumulation time, concentration of SDBS and solution pH, were optimized for ceftazidime detection.

Results: The carbon nanotube showed good electrocatalytic activity to the ceftazidime oxidation. The peak current of ceftazidime was greatly increased by SDBS. The detection linear range of this method was 2 to 55 µM and the detection limit was 0.11 µM.

Conclusion: The modified electrode in this work was simple to fabricate and it was used for the determination of ceftazidime in ceftazidime vial.

Keywords: Voltammetric determination, ceftazidime, carbon nanotube, electrode, sodium dodecyl, benzene sulphonate.

Graphical Abstract