Abstract

Background: Microwave technology is of great splendor in organic synthesis where it is applied efficaciously to synthesize a wide range of biologically active as well as industrially important compounds. Carbazole analogues are one of such important pharmacophores that are gaining considerable prominence nowadays. Besides their wide range of biological features, they possess opto-electronic as well as polymeric properties. This review highlights the entire progress of microwave assisted synthetic methodologies for carbazoles.

Methods: The key reactions are Fischer indolization, Suzuki-Miyaura cross-coupling, catalytic oxidative cyclization, cycloaddition and polymerization.

Conclusion: We have summarized a comprehensive reportage of these approaches to mild and efficient syntheses of carbazole under microwave irradiations.

Keywords: Carbazole, Microwave, Suzuki-Miyaura cross-couplings, Cadogan cyclization, Buchwald-Hartwig amination, Fischer indolization, Polymerization

Graphical Abstract