Abstract

Small molecule screens using C. elegans as a model are becoming increasingly popular as the number of high-throughput methodologies has steadily increased over the years. Here we focus on the biology that underlies this increased popularity and outline the reasons that make C. elegans an attractive model for drug discovery. We discuss successful C. elegans based drug discovery projects in the literature and future challenges ahead.

Keywords: C. elegans, Cancer biology, HTS, Nematodes, Vertebrate vascular endothelial growth factors, Drug discovery.