Sumoylation in Lens Differentiation and Pathogenesis

A.-P.      Arrigo; D.   W.-C.   Li; Y.-Z.      Liu; J.      Gigantelli; Q.      Sun; Y.-F.      Liu; Z.-W.      Luo; F.-Y.      Liu; S.      Huang; X.-C.      Tang; L.      Zhang; J.-W.      Xiang; T.-H.      Yang; R.-L.      Qi; Z.-X.      Huang; X.-H.      Hu; L.      Wang; W.-J.      Qing; Y.      Xiao; L.      Gong; Z.-G.      Chen

Current Molecular Medicine

Author(s): A.-P. Y.-Z. J. Q. Y.-F. Z.-W. F.-Y. S. X.-C. L. J.-W. T.-H. R.-L. Z.-X. X.-H. L. W.-J. Y. L. Z.-G. Arrigo, Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081,,China " data-bs-original-title="Affiliation">D. W.-C. Li, Liu, Gigantelli, Sun, Liu, Luo, Liu, Huang, Tang, Zhang, Xiang, Yang, Qi, Huang, Hu, Wang, Qing, Xiao, Gong and Chen

DOI: 10.2174/1566524017666170109123238

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Sumoylation in Lens Differentiation and Pathogenesis

Page: [859 - 870] Pages: 12

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Abstract

Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Keywords: Lens, sumoylation, differentiation, cataractogenesis, pathogenesis.

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