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Current Genomics

Author(s): John M. Yavorski, Rebecca J. Stoll, Mohammad D. Samy, James A. Mauro and George Blanck*

DOI: 10.2174/1389202918666170105093953

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Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome

Page: [287 - 297] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

Background: Relatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers.

Results: Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, including a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001).

Conclusion: Roles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein structures.

Keywords: Cytoskeletal and cell-adhesion genomics, Cancer genome atlas, Extra-cellular matrix, Melanoma stratification, Melanoma metastasis.

Graphical Abstract