Abstract

There is substantial evidence for the formation of Aβ and their conversion into toxic species under hyperglycemic condition. So, we can say that brain is one of the most important sites for diabetic end organ damage and AZ can be considered as a type of Diabetes. Till date we don’t have proper therapy for successful prevention of neuronal cell death in neurodegenerative diseases and research focuses to bring drugs that can either slow down disease progression or provide prophylaxis. However, Ayurveda that has numerous plants which can execute amazing and outstanding properties with (few) actions of herbs that are quite new to the conventional medicine. Polyphenolic compounds, found in various types of plant parts, that are antioxidant by nature having useful prophylactic properties for the treatment of excitotoxicity and oxidative cell death. Plants become source material for the development of drugs, as herbs have recently become attractive for targeting different pathologies as health-beneficial foods (physiologically functional foods). As an addition to various potent reviews that provided the therapeutic effect/efficacy information about various herbals as better neuro modulators, herein we have given up to date information of various phytoconstituents, polyherbal formulations and extracts which were found effective in the treatment of AZ. Although there are several herbals that have been proved to increase cognitive abilities, here we mentioned the herbals that were tested against various AZ insults.

Keywords: Alzheimer’s, diabetes mellitus, excitotoxicity, functional foods, neuronal plasticity, phosphorylation.

Graphical Abstract