Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

Sunetra      Jadhav; Ajinkya      Patravale; Reshma      Patil; Digambar      Kumbhar; Vishram      Karande; Dattatray      Chandam; Madhukar      Deshmukh

Current Green Chemistry

Author(s): Sunetra Jadhav, Ajinkya Patravale, Reshma Patil, Digambar Kumbhar, Vishram Karande, Dattatray Chandam and Madhukar Deshmukh*

DOI: 10.2174/2213346103666161115124757

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Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

Page: [227 - 234] Pages: 8

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Abstract

Background: A straightforward protocol for the one-pot synthesis of a series of novel thiazolopyrimidine derivatives has been developed.

Method: In which multicomponent reaction between thiobarbituric acid, 2-aminothiozole and several substituted aldehydes using sulfamic acid (20 mol%) as a heterogeneous and easily recoverable catalyst in ethanol under reflux condition.

Conclusion: This method has several advantages like greener synthetic approach, good to excellent yield (82-91%), cost-effectiveness, easy work-up and atom-economic procedure.

Keywords: 2-Aminothiazole, 2-thiobarbituric acid, thiazolopyrimidine derivatives, sulfamic acid, atom economy, multicomponent reaction.

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