Abstract

Background: Free radicals are frequently generated in vivo and their reactivity varies causing different damages to biological molecules, e.g. DNA, lipids, and proteins. Oxidative stress in the human body is due to the free radicals generation and to the reduced level of antioxidants. Antioxidants are able to reduce the risk for chronic diseases. Hence, natural and synthetic antioxidants may be predominantly significant in diminishing cumulative oxidative damage.

Objective: Many novel approaches have been made and significant progress has been done in the last years. This review shows current trend in the synthesis of pyrimidines and uracils and reveals their potent structures which can be a good source for the synthesis of new derivatives with required antioxidant activity.

Conclusion: These classes of compounds play an essential role in a variety of biological systems and have substantial attention in the field of pharmacology.

Keywords: Free radicals, antioxidants, pyrimidine, uracil, biological molecules, oxidative damage.

Graphical Abstract