Abstract

The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study from ancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drug development. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activities including antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with more selective activities and lower side effect continues to be an active area of argument examination in medicinal chemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, and anticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazole derivatives.

Keywords: 1, 3, 4-thiadiazole, cancer cell lines, structure-activity-relationship, mechanism of action.