Abstract

Introduction: An accurate and precise spectrophotometric method has been developed for the determination of the antiallergenic drug, promethazine with ruthenium (III).

Methods: The proposed method involves complexation of promethazine with Ru (III) (PM.Ru(III)) at 60ºC and λmax = 510 nm, which is applicable in pharmaceutical tablets and analytical data. The values for Beer's law, molar absorptivity, Sandell’s sensitivity, and mean correlation coefficient were determined to be 0.2-28 µg mL-1, 1.54 x 103 L mol-1cm-1, 0.021 and 0.9996, respectively.

Conclusion: The complex of promethazine with Ru(III) was characterised using FTIR, 1H-NMR, ESR, magnetic susceptibility, thermal (TG-DTA), and PXRD. The most plausible structure for the complex is reported with molecular formula [C37H52ClN4O2RuS2]·3Cl. The proposed method could be implemented for an easy and effective analysis for promethazine.

Keywords: Promethazine, drug, Ru(III), spectrophotometric, detection, FTIR.

Graphical Abstract