Abstract

Synthetic studies on the specific inhibitors of vacuolar-type H+-ATPase, bafilomycins, hygrolidines, and concanamycins, are described. Bafilomycins and hygrolidins are 16-membered and concanamycins are 18- membered plecomacrolides, which have very complex molecular structures.

Keywords: V-ATPase, hygrolidines, plecomacrolides