Abstract

Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity, insecticidal activity, antimicrobial activity, etc. The present review has summarized the biological activities and structural modifications of matrine and its derivatives focused on their N-1 position and lactam ring from 2010 to 2015. In addition, the mechanism of action and structure-activity relationships of matrine and its derivatives are discussed.

Keywords: Matrine derivatives, Biological activities, Structural modifications, Mechanism of action, Structure-activity relationship, Sophora flavescens.

Graphical Abstract