Abstract

Different synthetic strategies to 4,4-disubstituted pyridazines and condensed pyridazines with a special reference to the synthetic routes to their spiro analogues are comprehensively outlined in this review.

Keywords: Spirocyclic pyridazines, partially-saturated pyridazines, synthesis, retro- Diels-Alder, 1, 3-dipolar cycloaddition, Aza-Michael addition, nucleophilic reactions.