Abstract

Ethyl octyl phosphite (EOP), a dialkyl phosphite with mixed alkyl groups was prepared, and utilized in the Kabachnik–Fields reaction. The condensation of EOP, paraformaldehyde and primary or secondary amines used in equimolar quantities afforded new α-aminophosphonates under microwave conditions. Methylation of the -α(alkylamino)phosphonates was also investigated. The double phospha-Mannich reaction of primary amines and two equivalents of EOP and paraformaldehyde furnished new bis(phosphonomethyl)amines.

Keywords: Ethyl octyl phosphite, Kabachnik–Fields reaction, Ethyl octyl α-aminomethyl-phosphonates, N, N-Bis(ethyloctylphosphonoylmethyl) amines, Microwave.

Graphical Abstract